PROTAC Linker

Total: 1884
Updated: 2019-06-28 15:55:20
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.

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NF-κB IKK Keap1-Nrf2 MALT1
PI3K/Akt/mTOR >
Akt AMPK ATM/ATR DNA-PK GSK-3 MELK mTOR PDK-1 PI3K PI4K PIKfyve PTEN
PROTAC >
PROTAC E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase PROTAC Linker PROTAC-linker Conjugate for PAC
Protein Tyrosine Kinase/RTK >
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Vitamin D Related >
VD/VDR
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Acids and Aldehydes

1,3,4,6-Tetra-O-acetyl-2-[(azidoacetyl)amino]-2-deoxy-β-D-galactopyranos

Ac4GalNAz is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 653600-56-7
  • MF: C16H22N4O10
  • MW: 430.37
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG5-NHS ester

Azido-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1433996-86-1
  • MF: C17H28N4O9
  • MW: 432.426
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG8-azide

Azido-PEG8-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 361543-07-9
  • MF: C18H36N6O8
  • MW: 464.514
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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THP-PEG3-OH

THP-PEG3-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 60221-37-6
  • MF: C11H22O5
  • MW: 234.28900
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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2,5,8,11,14,17-Hexaoxanonadecan-19-ol

Hexaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 23601-40-3
  • MF: C13H28O7
  • MW: 296.357
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 375.6±37.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 180.9±26.5 °C
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Bis-sulfone-PEG4-DBCO

Bis-sulfone-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1854034-70-0
  • MF: C54H59N3O12S2
  • MW: 1006.19
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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3,6,9,12,15,18,21-Heptaoxatritriacontan-1-ol

Dodecylheptaglycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 3055-97-8
  • MF: C26H54O8
  • MW: 494.702
  • Catalog: PROTAC Linker
  • Density: 1.0±0.1 g/cm3
  • Boiling Point: 553.9±45.0 °C at 760 mmHg
  • Melting Point: 27-29 °C
  • Flash Point: 288.8±28.7 °C
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N-(Azido-PEG3)-N-(PEG2-amine)-PEG3-acid

N-(Azido-PEG3)-N-(PEG2-amine)-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2183440-70-0
  • MF: C24H47N5O11
  • MW: 581.66
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Mal-C6-amine TFA

Mal-C6-amine (TFA) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 731862-92-3
  • MF: C12H17F3N2O4
  • MW: 310.270
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG24-acid

m-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2248203-61-2
  • MF: C50H100O26
  • MW: 1117.31
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Bis-Biotin-PEG23

Bis-Biotin-PEG23 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 293298-36-9
  • MF: C68H128N6O27S2
  • MW: 1525.90
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG12-acid

Azido-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2152679-71-3
  • MF: C27H53N3O14
  • MW: 643.72
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Alkyne-PEG4-maleimide

Alkyne-PEG4-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1609651-90-2
  • MF: C18H26N2O7
  • MW: 382.408
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 575.8±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 302.1±30.1 °C
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Leukotriene B4

Leukotriene B4 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 71160-24-2
  • MF: C20H32O4
  • MW: 336.466
  • Catalog: PROTAC Linker
  • Density: 1.0±0.1 g/cm3
  • Boiling Point: 536.4±50.0 °C at 760 mmHg
  • Melting Point: -144.0 °C (lit.)
  • Flash Point: 292.3±26.6 °C
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Bis-PEG11-acid

Bis-PEG11-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2097010-30-3
  • MF: C26H50O15
  • MW: 602.67
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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NH-bis-PEG4

NH-bis-PEG4 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 63721-14-2
  • MF: C16H35NO8
  • MW: 369.451
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 482.3±40.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 245.5±27.3 °C
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N-Mal-N-bis(PEG2-acid)

N-Mal-N-bis(PEG2-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2110449-02-8
  • MF: C21H32N2O11
  • MW: 488.49
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Alkyne-ethyl-PEG1-t-Butyl ester

Alkyne-ethyl-PEG1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2100306-55-4
  • MF: C11H18O3
  • MW: 198.26
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG7-alcohol

Azido-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1274892-60-2
  • MF: C14H29N3O7
  • MW: 351.40
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG5-Boc

Azido-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1448451-72-6
  • MF: C16H31N3O7
  • MW: 377.433
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Thiol-PEG4-alcohol

Thiol-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 90952-27-5
  • MF: C8H18O4S
  • MW: 210.29100
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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cis-4-Hydroxy-L-proline hydrochloride

cis-4-Hydroxy-L-proline hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-L-proline hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].

  • CAS Number: 441067-49-8
  • MF: C5H10ClNO3
  • MW: 167.591
  • Catalog: ADC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Ald-Ph-amido-PEG3-C2-NH2

Ald-Ph-amido-PEG3-C2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1404111-56-3
  • MF: C16H24N2O5
  • MW: 324.372
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 542.8±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 282.1±30.1 °C
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Bis-PEG4-PFP ester

Bis-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1314378-12-5
  • MF: C24H20F10O8
  • MW: 626.395
  • Catalog: PROTAC Linker
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 570.5±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 287.7±25.0 °C
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Methyltetrazine-PEG4-amine HCl

Methyltetrazine-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1802908-05-9
  • MF: C17H25N5O4
  • MW: 363.411
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 558.7±60.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 291.7±32.9 °C
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t-Boc-Aminooxy-PEG2-CH2CO2H

Boc-Aminooxy-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2098983-14-1
  • MF: C11H21NO7
  • MW: 279.29
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG2-azide

Azido-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 59559-06-7
  • MF: C6H12N6O2
  • MW: 200.19800
  • Catalog: PROTAC Linker
  • Density: 1.15 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Ald-CH2-PEG4-CH2CO2tBu

Ald-CH2-PEG3-CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of SGK3 kinase PROTAC degrader[1].

  • CAS Number: 2100306-54-3
  • MF: C14H26O7
  • MW: 306.35
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Biotin-PEG11-Mal

Biotin-PEG11-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1646619-56-8
  • MF: C41H71N5O16S
  • MW: 922.09
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Ms-PEG6-Ms

Ms-PEG6-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 109789-40-4
  • MF: C14H34O13S2
  • MW: 474.54200
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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