NH-bis-PEG4

Modify Date: 2024-01-06 14:04:20

NH-bis-PEG4 Structure
NH-bis-PEG4 structure
Common Name NH-bis-PEG4
CAS Number 63721-14-2 Molecular Weight 369.451
Density 1.1±0.1 g/cm3 Boiling Point 482.3±40.0 °C at 760 mmHg
Molecular Formula C16H35NO8 Melting Point N/A
MSDS N/A Flash Point 245.5±27.3 °C

 Use of NH-bis-PEG4


NH-bis-PEG4 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name NH-(PEG3-OH)2
Synonym More Synonyms

 NH-bis-PEG4 Biological Activity

Description NH-bis-PEG4 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 482.3±40.0 °C at 760 mmHg
Molecular Formula C16H35NO8
Molecular Weight 369.451
Flash Point 245.5±27.3 °C
Exact Mass 369.236267
LogP -3.13
Vapour Pressure 0.0±2.7 mmHg at 25°C
Index of Refraction 1.470

 Synonyms

MFCD29912667
3,6,9,15,18,21-Hexaoxa-12-azatricosane-1,23-diol
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