NH-bis-PEG4

Names

[ CAS No. ]:
63721-14-2

[ Name ]:
NH-bis-PEG4

[Synonym ]:
MFCD29912667
3,6,9,15,18,21-Hexaoxa-12-azatricosane-1,23-diol

Biological Activity

[Description]:

NH-bis-PEG4 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
482.3±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₃₅NO₈

[ Molecular Weight ]:
369.451

[ Flash Point ]:
245.5±27.3 °C

[ Exact Mass ]:
369.236267

[ LogP ]:
-3.13

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.470

NH-bis-PEG4

Names

Biological Activity

Chemical & Physical Properties

Related Compounds