Leukotriene B4
Leukotriene B4 structure
|
Common Name | Leukotriene B4 | ||
|---|---|---|---|---|
| CAS Number | 71160-24-2 | Molecular Weight | 336.466 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 536.4±50.0 °C at 760 mmHg | |
| Molecular Formula | C20H32O4 | Melting Point | -144.0 °C (lit.) | |
| MSDS | USA | Flash Point | 292.3±26.6 °C | |
| Symbol |
GHS02, GHS07 |
Signal Word | Danger | |
Use of Leukotriene B4Leukotriene B4 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
| Name | leukotriene B4 |
|---|---|
| Synonym | More Synonyms |
| Description | Leukotriene B4 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl-Chain Human Endogenous Metabolite |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 536.4±50.0 °C at 760 mmHg |
| Melting Point | -144.0 °C (lit.) |
| Molecular Formula | C20H32O4 |
| Molecular Weight | 336.466 |
| Flash Point | 292.3±26.6 °C |
| Exact Mass | 336.230072 |
| PSA | 77.76000 |
| LogP | 4.06 |
| Vapour Pressure | 0.0±3.2 mmHg at 25°C |
| Index of Refraction | 1.527 |
| Storage condition | −20°C |
| Symbol |
GHS02, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H319 |
| Precautionary Statements | P210-P280-P305 + P351 + P338-P337 + P313-P403 + P235 |
| Hazard Codes | F: Flammable; |
| Risk Phrases | 11 |
| Safety Phrases | S7-S16 |
| RIDADR | UN 1170 3/PG 2 |
| WGK Germany | 1 |
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HMDB: a knowledgebase for the human metabolome.
Nucleic Acids Res. 37(Database issue) , D603-10, (2009) The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, ... |
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The human serum metabolome.
PLoS ONE 6(2) , e16957, (2011) Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the m... |
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Tulathromycin exerts proresolving effects in bovine neutrophils by inhibiting phospholipases and altering leukotriene B4, prostaglandin E2, and lipoxin A4 production.
Antimicrob. Agents Chemother. 58(8) , 4298-307, (2014) The accumulation of neutrophils and proinflammatory mediators, such as leukotriene B4 (LTB4), is a classic marker of inflammatory disease. The clearance of apoptotic neutrophils, inhibition of proinfl... |
| (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-6,8,10,14-icosatetraenoic acid |
| Leukotriene B4 |
| 6Z,8E,10E,14Z,5S,12R-diHETE |
| (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxyicosa-6,8,10,14-tetraenoic acid |
| EINECS 200-578-6 |
| LTB4 |
| Leukotriene B4,(5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-6,8,10,14-eicosatetraenoicacid |
| Leukotriene B4 Lipid Maps MS Standard |
| MFCD00135630 |
| 6,8,10,14-Eicosatetraenoic acid, 5,12-dihydroxy-, (5S,6Z,8E,10E,12R,14Z)- |