Thiol-PEG4-alcohol

Modify Date: 2024-01-09 16:06:47

Thiol-PEG4-alcohol Structure
Thiol-PEG4-alcohol structure
Common Name Thiol-PEG4-alcohol
CAS Number 90952-27-5 Molecular Weight 210.29100
Density N/A Boiling Point N/A
Molecular Formula C8H18O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Thiol-PEG4-alcohol


Thiol-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-[2-(2-sulfanylethoxy)ethoxy]ethoxy]ethanol
Synonym More Synonyms

 Thiol-PEG4-alcohol Biological Activity

Description Thiol-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Molecular Formula C8H18O4S
Molecular Weight 210.29100
Exact Mass 210.09300
PSA 86.72000

 Safety Information

Hazard Codes C

 Synthetic Route

~81%

Thiol-PEG4-alcohol Structure

Thiol-PEG4-alcohol

CAS#:90952-27-5

Literature: Pan, Hongmu; Grow, Margaret E.; Wilson, Orla; Daniel, Marie-Christine Tetrahedron, 2013 , vol. 69, # 13 p. 2799 - 2806

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Thiol-PEG4-alcohol Structure

Thiol-PEG4-alcohol

CAS#:90952-27-5

Literature: Payre, Nathalie; Cottaz, Sylvain; Boisset, Claire; Borsali, Redouane; Svensson, Birte; Henrissat, Bernard; Driguez, Hugues Angewandte Chemie - International Edition, 1999 , vol. 38, # 7 p. 974 - 977

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Thiol-PEG4-alcohol Structure

Thiol-PEG4-alcohol

CAS#:90952-27-5

Literature: Payre, Nathalie; Cottaz, Sylvain; Boisset, Claire; Borsali, Redouane; Svensson, Birte; Henrissat, Bernard; Driguez, Hugues Angewandte Chemie - International Edition, 1999 , vol. 38, # 7 p. 974 - 977

~%

Thiol-PEG4-alcohol Structure

Thiol-PEG4-alcohol

CAS#:90952-27-5

Literature: Payre, Nathalie; Cottaz, Sylvain; Boisset, Claire; Borsali, Redouane; Svensson, Birte; Henrissat, Bernard; Driguez, Hugues Angewandte Chemie - International Edition, 1999 , vol. 38, # 7 p. 974 - 977

~%

Thiol-PEG4-alcohol Structure

Thiol-PEG4-alcohol

CAS#:90952-27-5

Literature: Payre, Nathalie; Cottaz, Sylvain; Boisset, Claire; Borsali, Redouane; Svensson, Birte; Henrissat, Bernard; Driguez, Hugues Angewandte Chemie - International Edition, 1999 , vol. 38, # 7 p. 974 - 977

~%

Thiol-PEG4-alcohol Structure

Thiol-PEG4-alcohol

CAS#:90952-27-5

Literature: Bartz, Marcus; Kuether, Joerg; Nelles, Gabriele; Weber, Nicole; Seshadri, Ram; Tremel, Wolfgang Journal of Materials Chemistry, 1999 , vol. 9, # 5 p. 1121 - 1125

 Synonyms

11-mercapto-3,6,9-trioxaundecanol
Ethanol,2-[2-[2-(2-mercaptoethoxy)ethoxy]ethoxy]
tetraethylene glycol monothiol
11-mercapto-3,6,9-trioxyundecan-1-ol
12-mercapto-3,6,9,12-tetraoxadodecan-1-ol
1-mercapto-11-hydroxy-3,6,9-trioxaundecane
mercaptotetraethylene glycol