Dynamic Light Scattering Evidence for a Ligand??Induced Motion between the Two Domains of Glucoamylase G1 of Aspergillus niger with Heterobivalent Substrate …

…, B Svensson, B Henrissat, H Driguez

Index: Payre, Nathalie; Cottaz, Sylvain; Boisset, Claire; Borsali, Redouane; Svensson, Birte; Henrissat, Bernard; Driguez, Hugues Angewandte Chemie - International Edition, 1999 , vol. 38, # 7 p. 974 - 977

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Citation Number: 14

Abstract

Abstract Heterobifunctional ligands that bind at the same time to the catalytic domain and to the starch-binding domain of glucoamylase induce a conformational change of the protein, as shown by dynamic light scattering. The ligands consist of acarbose and β-cyclodextrin linked together by oligoethylene glycols of variable length (see the schematic diagram).