Thiol-PEG4-alcohol

Names

[ Name ]:
Thiol-PEG4-alcohol

[Synonym ]:
11-mercapto-3,6,9-trioxaundecanol
Ethanol,2-[2-[2-(2-mercaptoethoxy)ethoxy]ethoxy]
tetraethylene glycol monothiol
11-mercapto-3,6,9-trioxyundecan-1-ol
12-mercapto-3,6,9,12-tetraoxadodecan-1-ol
1-mercapto-11-hydroxy-3,6,9-trioxaundecane
mercaptotetraethylene glycol

Biological Activity

[Description]:

Thiol-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈H₁₈O₄S

[ Molecular Weight ]:
210.29100

[ Exact Mass ]:
210.09300

[ PSA ]:
86.72000

Safety Information

[ Hazard Codes ]:
C

Thiol-PEG4-alcohol

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

Click to get detail synthetic route

Related Compounds