59559-06-7
59559-06-7 structure
- Name: Azido-PEG2-azide
- Chemical Name: 1,8-Diazido-3,6-dioxaoctane
- CAS Number: 59559-06-7
- Molecular Formula: C6H12N6O2
- Molecular Weight: 200.19800
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2016-11-18 00:14:56
- Modify Date: 2024-01-10 17:00:24
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Azido-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | 1,8-Diazido-3,6-dioxaoctane |
|---|---|
| Synonyms |
1,8-Diazido-3,5-dioxaoctane
bis-1,2-(2-azidoethoxy)ethane diazido triethyleneglycol 1,2-bis(2-azidoethoxy)-ethane 1-Azido-2-[2-(2-azidoethoxy)ethoxy]ethane |
| Description | Azido-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.15 g/cm3 |
|---|---|
| Molecular Formula | C6H12N6O2 |
| Molecular Weight | 200.19800 |
| Exact Mass | 200.10200 |
| PSA | 117.96000 |
| LogP | 0.89332 |
|
~10%
59559-06-7 |
| Literature: Gavrilyuk, Julia I.; Wuellner, Ulrich; Barbas III, Carlos F. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 5 p. 1421 - 1424 |
|
~96%
59559-06-7 |
| Literature: Klein, Emmanuel; DeBonis, Salvatore; Thiede, Bernd; Skoufias, Dimitrios A.; Kozielski, Frank; Lebeau, Luc Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 19 p. 6474 - 6488 |
|
~90%
59559-06-7 |
| Literature: Xiao, Junpeng; Tolbert, Thomas J. Organic Letters, 2009 , vol. 11, # 18 p. 4144 - 4147 |
|
~83%
59559-06-7 |
| Literature: Li, Yi; Dong, Jianming; Xun, Zhiqing; Zeng, Yi; Yu, Tianjun; Han, Yongbin; Chen, Jinping; Li, Ying-Ying; Yang, Guoqiang Chemistry - A European Journal, 2013 , vol. 19, # 24 p. 7931 - 7936 |
|
~%
59559-06-7 |
| Literature: Bouzide, Abderrahim; LeBerre, Nicolas; Sauve, Gilles Tetrahedron Letters, 2001 , vol. 42, # 50 p. 8781 - 8783 |
| Precursor 4 | |
|---|---|
| DownStream 6 | |
