DC Chemicals Limited
China
Product Name: Azide-PEG3-Azide
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,8-Diazido-3,5-dioxaoctane
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

59559-06-7

59559-06-7 structure

59559-06-7 structure

Name: Azido-PEG2-azide
Chemical Name: 1,8-Diazido-3,6-dioxaoctane
CAS Number: 59559-06-7
Molecular Formula: C₆H₁₂N₆O₂
Molecular Weight: 200.19800
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2016-11-18 00:14:56
Modify Date: 2024-01-10 17:00:24
Azido-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	1,8-Diazido-3,6-dioxaoctane
Synonyms	1,8-Diazido-3,5-dioxaoctane bis-1,2-(2-azidoethoxy)ethane diazido triethyleneglycol 1,2-bis(2-azidoethoxy)-ethane 1-Azido-2-[2-(2-azidoethoxy)ethoxy]ethane

Description	Azido-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Density	1.15 g/cm3
Molecular Formula	C₆H₁₂N₆O₂
Molecular Weight	200.19800
Exact Mass	200.10200
PSA	117.96000
LogP	0.89332

19249-03-7 structure

19249-03-7

~10%

59559-06-7 structure

59559-06-7

Literature: Gavrilyuk, Julia I.; Wuellner, Ulrich; Barbas III, Carlos F. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 5 p. 1421 - 1424

112-26-5 structure

112-26-5

~96%

59559-06-7 structure

59559-06-7

Literature: Klein, Emmanuel; DeBonis, Salvatore; Thiede, Bernd; Skoufias, Dimitrios A.; Kozielski, Frank; Lebeau, Luc Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 19 p. 6474 - 6488

117013-39-5 structure

117013-39-5

~90%

59559-06-7 structure

59559-06-7

Literature: Xiao, Junpeng; Tolbert, Thomas J. Organic Letters, 2009 , vol. 11, # 18 p. 4144 - 4147

31255-10-4 structure

31255-10-4

~83%

59559-06-7 structure

59559-06-7

Literature: Li, Yi; Dong, Jianming; Xun, Zhiqing; Zeng, Yi; Yu, Tianjun; Han, Yongbin; Chen, Jinping; Li, Ying-Ying; Yang, Guoqiang Chemistry - A European Journal, 2013 , vol. 19, # 24 p. 7931 - 7936

112-27-6 structure

112-27-6

~%

59559-06-7 structure

59559-06-7

Literature: Bouzide, Abderrahim; LeBerre, Nicolas; Sauve, Gilles Tetrahedron Letters, 2001 , vol. 42, # 50 p. 8781 - 8783

Precursor 4
19249-03-7 112-26-5 31255-10-4 112-27-6
DownStream 6
31249-95-3 929-59-9 30989-20-9 153086-78-3
166388-57-4 660843-23-2