166388-57-4

166388-57-4 structure

Name: Azido-PEG2-C2-amine
Chemical Name: 2-[2-(2-azidoethoxy)ethoxy]ethanamine
CAS Number: 166388-57-4
Molecular Formula: C₆H₁₄N₄O₂
Molecular Weight: 174.20100
Catalog: Chemical reagent Organic reagent Azide
Create Date: 2019-02-04 12:06:26
Modify Date: 2024-01-02 12:05:23
Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG2-C2-amine is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

Name	2-[2-(2-azidoethoxy)ethoxy]ethanamine
Synonyms	2-(2-(2-azidoethoxy)exthoxy)ethanamine 1-AMINO-8-AZIDO-3,5-DIOXAOCTANE Amino-PEG2-Azide 2-azidoethyloxyethyloxyethylamine 2-(2-(2-azidoethoxy)ethoxy)ethanamine 1-(2-AMINOETHOXY)-2-(2-AZIDOETHOXY)ETHANE 2-[2-(2-azidoethoxy)-ethoxy]-ethylamine

Description	Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG2-C2-amine is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Non-cleavable
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
References	[1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. [2]. Tominari, Yusuk , et al. Heterocyclic compound. WO2020027225A1.