Azido-PEG2-C2-amine
Azido-PEG2-C2-amine structure
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Common Name | Azido-PEG2-C2-amine | ||
|---|---|---|---|---|
| CAS Number | 166388-57-4 | Molecular Weight | 174.20100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C6H14N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Azido-PEG2-C2-amineAzido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG2-C2-amine is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
| Name | 2-[2-(2-azidoethoxy)ethoxy]ethanamine |
|---|---|
| Synonym | More Synonyms |
| Description | Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG2-C2-amine is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
|---|---|
| Related Catalog | |
| Target |
PEGs Non-cleavable |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
| References |
[2]. Tominari, Yusuk , et al. Heterocyclic compound. WO2020027225A1. |
| Molecular Formula | C6H14N4O2 |
|---|---|
| Molecular Weight | 174.20100 |
| Exact Mass | 174.11200 |
| PSA | 94.23000 |
| LogP | 0.44166 |
| Storage condition | 2-8°C |
|
~99%
Azido-PEG2-C2-amine CAS#:166388-57-4 |
| Literature: Klein, Emmanuel; DeBonis, Salvatore; Thiede, Bernd; Skoufias, Dimitrios A.; Kozielski, Frank; Lebeau, Luc Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 19 p. 6474 - 6488 |
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~76%
Azido-PEG2-C2-amine CAS#:166388-57-4 |
| Literature: Li, Ying; Schaffer, Paul; Perrin, David M. Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 23 p. 6313 - 6316 |
|
~57%
Azido-PEG2-C2-amine CAS#:166388-57-4 |
| Literature: Lu, Yan; Gervay-Hague, Jacquelyn Carbohydrate Research, 2007 , vol. 342, # 12-13 p. 1636 - 1650 |
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~%
Azido-PEG2-C2-amine CAS#:166388-57-4 |
| Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 6 p. 1499 - 1503 |
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~%
Azido-PEG2-C2-amine CAS#:166388-57-4 |
| Literature: Zheng, Hong; Wang, Fang; Wang, Qin; Gao, Jianmin Journal of the American Chemical Society, 2011 , vol. 133, # 39 p. 15280 - 15283 |
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~%
Azido-PEG2-C2-amine CAS#:166388-57-4 |
| Literature: Carbohydrate Research, , vol. 342, # 12-13 p. 1636 - 1650 |
|
~%
Azido-PEG2-C2-amine CAS#:166388-57-4 |
| Literature: Journal of the American Chemical Society, , vol. 133, # 39 p. 15280 - 15283 |
|
~%
Azido-PEG2-C2-amine CAS#:166388-57-4 |
| Literature: Journal of the American Chemical Society, , vol. 134, # 45 p. 18809 - 18815 |
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~%
Azido-PEG2-C2-amine CAS#:166388-57-4 |
| Literature: Journal of the American Chemical Society, , vol. 134, # 45 p. 18809 - 18815 |
| 2-(2-(2-azidoethoxy)exthoxy)ethanamine |
| 1-AMINO-8-AZIDO-3,5-DIOXAOCTANE |
| Amino-PEG2-Azide |
| 2-azidoethyloxyethyloxyethylamine |
| 2-(2-(2-azidoethoxy)ethoxy)ethanamine |
| 1-(2-AMINOETHOXY)-2-(2-AZIDOETHOXY)ETHANE |
| 2-[2-(2-azidoethoxy)-ethoxy]-ethylamine |