ethylene glycol bis(2-aminoethyl) ether

Modify Date: 2024-01-03 11:31:50

ethylene glycol bis(2-aminoethyl) ether Structure
ethylene glycol bis(2-aminoethyl) ether structure
Common Name ethylene glycol bis(2-aminoethyl) ether
CAS Number 929-59-9 Molecular Weight 148.203
Density 1.0±0.1 g/cm3 Boiling Point 241.0±20.0 °C at 760 mmHg
Molecular Formula C6H16N2O2 Melting Point N/A
MSDS Chinese USA Flash Point 104.3±15.5 °C
Symbol GHS05 GHS07 GHS08
GHS05, GHS07, GHS08
Signal Word Danger

 Use of ethylene glycol bis(2-aminoethyl) ether


PROTAC Linker 19 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 19 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

 Names

Name 1,8-Diamino-3,6-dioxaoctane
Synonym More Synonyms

 ethylene glycol bis(2-aminoethyl) ether Biological Activity

Description PROTAC Linker 19 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 19 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Related Catalog
Target

Alkyl/ether

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 241.0±20.0 °C at 760 mmHg
Molecular Formula C6H16N2O2
Molecular Weight 148.203
Flash Point 104.3±15.5 °C
Exact Mass 148.121185
PSA 70.50000
LogP -1.59
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.460

 Safety Information

Symbol GHS05 GHS07 GHS08
GHS05, GHS07, GHS08
Signal Word Danger
Hazard Statements H302-H314-H317-H334
Precautionary Statements P261-P280-P305 + P351 + P338-P310
Personal Protective Equipment Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes C:Corrosive;
Risk Phrases R22;R34;R42/43
Safety Phrases S23-S26-S36/37/39-S45
RIDADR UN 2735 8/PG 2
WGK Germany 3
Packaging Group III
Hazard Class 8
HS Code 2922199090

 Synthetic Route

~81%

ethylene glycol bis(2-aminoethyl) ether Structure

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CAS#:929-59-9

Literature: Journal of Heterocyclic Chemistry, , vol. 18, p. 297 - 302

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ethylene glycol bis(2-aminoethyl) ether Structure

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CAS#:929-59-9

Literature: Journal of Organic Chemistry, , vol. 46, # 15 p. 3064 - 3070

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ethylene glycol bis(2-aminoethyl) ether Structure

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CAS#:929-59-9

Literature: Journal of Organic Chemistry, , vol. 39, p. 1315 - 1316

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Literature: Journal of Heterocyclic Chemistry, , vol. 24, p. 1077 - 1083

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ethylene glycol bis(2-aminoethyl) ether Structure

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CAS#:929-59-9

Literature: Journal of Organic Chemistry USSR (English Translation), , vol. 16, p. 1124 - 1129 Zhurnal Organicheskoi Khimii, , vol. 16, # 6 p. 1301 - 1307

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ethylene glycol bis(2-aminoethyl) ether Structure

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CAS#:929-59-9

Literature: Journal of Organic Chemistry USSR (English Translation), , vol. 16, p. 1124 - 1129 Zhurnal Organicheskoi Khimii, , vol. 16, # 6 p. 1301 - 1307

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 Customs

HS Code 2922199090
Summary 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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 Synonyms

2,2′-(ethylenedioxy)bis(ethylamine)
1,8-diaminotriethyleneglycol
MFCD00040474
2,2'-[1,2-Ethanediylbis(oxy)]diethanamine
2,2'-[ethane-1,2-diylbis(oxy)]diethanamine
1,2-Bis(2-aminoethoxy)ethane
UNII-R41ZT4UF34
Jeffamine® EDR-176
EDR-148
TRIETHYLENEGLYCOLDIAMINE
1,8-Diamino-3,6-dioxaoctane
DA-10
Jeffamine(R) EDR-176
2,2'-(Ethylenedioxy)bis(ethylamine)
1,8-diamino-3,6-dioxa-octane
3,6-dioxaoctamethylenediamine
Ethanamine, 2,2'-(1,2-ethanediylbis(oxy))bis-
3,6-dioxa-1,8-octanediamine
EINECS 213-203-6
Ethanamine, 2,2'-[1,2-ethanediylbis(oxy)]bis-
Jeffamine EDR-148
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