36839-55-1

36839-55-1 structure

Name: Iodo-PEG3-Iodide
Chemical Name: 1,2-Bis(2-iodoethoxy)ethane
CAS Number: 36839-55-1
Molecular Formula: C₆H₁₂I₂O₂
Molecular Weight: 369.96700
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-24 12:20:11
Modify Date: 2024-01-03 08:50:13
1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of MT802 (HY-122562) and SJF620 (HY-133137). MT-802 and SJF620 are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively[1].

Name	1,2-Bis(2-iodoethoxy)ethane
Synonyms	Ethylene Glycol Bis(2-iodoethyl) Ether 1,2-BIS(2-IODOETHOXY)ETHANE MFCD00075008

Description	1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of MT802 (HY-122562) and SJF620 (HY-133137). MT-802 and SJF620 are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	1,2-Bis(2-iodoethoxy)ethane is a PROTAC linker, which refers to the PEG composition. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of a series of PROTACs, such as MT802 (HY-122562) and SJF620 (HY-133137). PROTAC MT802（HY-122562） has a ligand specific for BTK, and a ligand specific to a E3 ligase cereblon (CRBN) connected by polyethylene glycol (PEG) linker 1,2-Bis(2-iodoethoxy)ethane[1].
References	[1]. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.

Density	2.028 g/mL at 25 °C(lit.)
Boiling Point	293.5ºC at 760 mmHg
Molecular Formula	C₆H₁₂I₂O₂
Molecular Weight	369.96700
Flash Point	>230 °F
Exact Mass	369.89300
PSA	18.46000
LogP	1.88960
Index of Refraction	n20/D 1.572(lit.)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2909199090

19249-03-7

~89%

36839-55-1

Literature: Aoki, Yuko; Umezawa, Naoki; Asano, Yuko; Hatano, Keiichiro; Yano, Yuki; Kato, Nobuki; Higuchi, Tsunehiko Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 22 p. 7108 - 7115

117013-39-5

~89%

36839-55-1

Literature: Zhao, Ya-Nan; Yang, Zhen-Zhen; Luo, Si-Hang; He, Liang-Nian Catalysis Today, 2013 , vol. 200, # 1 p. 2 - 8

80322-82-3

~55%

36839-55-1

Literature: Jensen, Marie; Schmidt, Steffen; Fedosova, Natalya U.; Mollenhauer, Jan; Jensen, Henrik H. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 7 p. 2407 - 2417

112-26-5

~92%

36839-55-1

Literature: Crossley, Roger; Goolamali, Zia; Gosper, Jeffrey J.; Sammes, Peter G. Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1994 , # 3 p. 513 - 520

112-27-6

36839-55-1

Literature: Provencher-Mandeville, Josee; Debnath, Chhanda; Mandal, Sanat K.; Leblanc, Valerie; Parent, Sophie; Asselin, Eric; Berube, Gervais Steroids, 2011 , vol. 76, # 1-2 p. 94 - 103

Precursor 4
19249-03-7 80322-82-3 112-26-5 112-27-6
DownStream 10
31249-95-3 31364-42-8 31250-18-7 69703-25-9
23978-55-4 23978-09-8 119017-39-9 117875-33-9
119017-40-2 23978-10-1

HS Code	2909199090
Summary	2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

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