Iodo-PEG3-Iodide

Modify Date: 2025-08-25 21:39:26

Iodo-PEG3-Iodide structure	Common Name	Iodo-PEG3-Iodide
	CAS Number	36839-55-1	Molecular Weight	369.96700
	Density	2.028 g/mL at 25 °C(lit.)	Boiling Point	293.5ºC at 760 mmHg
	Molecular Formula	C₆H₁₂I₂O₂	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	>230 °F
	Symbol	GHS07	Signal Word	Warning

Use of Iodo-PEG3-Iodide

1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of MT802 (HY-122562) and SJF620 (HY-133137). MT-802 and SJF620 are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively[1].

Name	1,2-Bis(2-iodoethoxy)ethane
Synonym	More Synonyms

Description	1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of MT802 (HY-122562) and SJF620 (HY-133137). MT-802 and SJF620 are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	1,2-Bis(2-iodoethoxy)ethane is a PROTAC linker, which refers to the PEG composition. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of a series of PROTACs, such as MT802 (HY-122562) and SJF620 (HY-133137). PROTAC MT802（HY-122562） has a ligand specific for BTK, and a ligand specific to a E3 ligase cereblon (CRBN) connected by polyethylene glycol (PEG) linker 1,2-Bis(2-iodoethoxy)ethane[1].
References	[1]. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.

Density	2.028 g/mL at 25 °C(lit.)
Boiling Point	293.5ºC at 760 mmHg
Molecular Formula	C₆H₁₂I₂O₂
Molecular Weight	369.96700
Flash Point	>230 °F
Exact Mass	369.89300
PSA	18.46000
LogP	1.88960
Index of Refraction	n20/D 1.572(lit.)

Iodo-PEG3-Iodide MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2909199090

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Literature: Crossley, Roger; Goolamali, Zia; Gosper, Jeffrey J.; Sammes, Peter G. Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1994 , # 3 p. 513 - 520

Triethylene glycol

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Iodo-PEG3-Iodide

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Literature: Provencher-Mandeville, Josee; Debnath, Chhanda; Mandal, Sanat K.; Leblanc, Valerie; Parent, Sophie; Asselin, Eric; Berube, Gervais Steroids, 2011 , vol. 76, # 1-2 p. 94 - 103

Precursor 4
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DownStream 10
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HS Code	2909199090
Summary	2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

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MFCD00075008

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Iodo-PEG3-Iodide
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Iodo-PEG3-Iodide
Price: ￥428.0/5g
Purity: 98.0%
Delivery: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Iodo-PEG3-Iodide
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,2-bis(2-iodoethoxy)ethane
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Annale (Qihe) New Material Technology Co., Ltd
China
Product Name: Iodo-PEG3-Iodide
Price: ￥Inquiry/1kg
Purity: 97.0%
Delivery: 3 Day
Contact: Clement
Email: 1584468135@qq.com

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