Bromo-PEG2-bromide
Modify Date: 2024-01-11 19:06:08
Bromo-PEG2-bromide structure
|
Common Name | Bromo-PEG2-bromide | ||
|---|---|---|---|---|
| CAS Number | 31255-10-4 | Molecular Weight | 275.96600 | |
| Density | 1.655 g/cm3 | Boiling Point | 285.1ºC at 760 mmHg | |
| Molecular Formula | C6H12Br2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 113.8ºC | |
Use of Bromo-PEG2-bromideBromo-PEG2-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. |
| Name | 1,2-bis(2-bromoethoxy)ethane |
|---|---|
| Synonym | More Synonyms |
| Description | Bromo-PEG2-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.655 g/cm3 |
|---|---|
| Boiling Point | 285.1ºC at 760 mmHg |
| Molecular Formula | C6H12Br2O2 |
| Molecular Weight | 275.96600 |
| Flash Point | 113.8ºC |
| Exact Mass | 273.92000 |
| PSA | 18.46000 |
| LogP | 1.80940 |
| Storage condition | 2-8°C |
|
~90%
Bromo-PEG2-bromide CAS#:31255-10-4 |
| Literature: Li, Yi; Dong, Jianming; Xun, Zhiqing; Zeng, Yi; Yu, Tianjun; Han, Yongbin; Chen, Jinping; Li, Ying-Ying; Yang, Guoqiang Chemistry - A European Journal, 2013 , vol. 19, # 24 p. 7931 - 7936 |
|
~58%
Bromo-PEG2-bromide CAS#:31255-10-4 |
| Literature: Farina, Paolo; Latter, Thomas; Levason, William; Reid, Gillian Dalton Transactions, 2013 , vol. 42, # 13 p. 4714 - 4724 |
|
~77%
Bromo-PEG2-bromide CAS#:31255-10-4 |
| Literature: Holmes, Brian T.; Snow, Arthur W. Patent: US2009/187037 A1, 2009 ; Location in patent: Page/Page column 2-3 ; |
|
~%
Bromo-PEG2-bromide CAS#:31255-10-4 |
| Literature: Rabouin, Daniel; Perron, Valerie; N'Zemba, Blaise; C.-Gaudreault, Rene; Berube, Gervais Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 3 p. 557 - 560 Title/Abstract Full Text View citing articles Show Details Berube, Gervais; Rabouin, Daniel; Perron, Valerie; N'Zemba, Blaise; Gaudreault, Rene-C.; Parent, Sophie; Asselin, Eric Steroids, 2006 , vol. 71, # 10 p. 911 - 921 |
|
~%
Bromo-PEG2-bromide CAS#:31255-10-4 |
| Literature: Mamedov,S.; Agaev,A.S. J. Gen. Chem. USSR (Engl. Transl.), 1963 , vol. 33, # 10 p. 3166 - 3171,3093 - 3098 |
|
~%
Bromo-PEG2-bromide CAS#:31255-10-4 |
| Literature: Movsumzade,M.M. et al. Journal of Organic Chemistry USSR (English Translation), 1972 , vol. 8, p. 2077 - 2079 Zhurnal Organicheskoi Khimii, 1972 , vol. 8, # 10 p. 2031 - 2034 |
|
~%
Bromo-PEG2-bromide CAS#:31255-10-4 |
| Literature: Nesmejanow et al. Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1951 , p. 708,709 Chem.Abstr., 1952 , p. 7514 |
|
~%
Bromo-PEG2-bromide CAS#:31255-10-4 |
| Literature: Delaney, Paul A.; Johnstone, Robert A. W.; Entwistle, Ian D. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 1855 - 1860 |
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| Precursor 8 | |
|---|---|
| DownStream 10 | |
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