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57641-66-4

57641-66-4 structure
57641-66-4 structure
  • Name: Bromo-PEG2-alcohol
  • Chemical Name: 2-(2-Bromoethoxy)ethanol
  • CAS Number: 57641-66-4
  • Molecular Formula: C4H9BrO2
  • Molecular Weight: 169.01700
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-20 21:25:29
  • Modify Date: 2025-08-21 17:36:43
  • Bromo-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Name 2-(2-Bromoethoxy)ethanol
Synonyms 2-(2-bromoethoxy)benzoic aldehyde
2-(2'-bromoethoxy)ethanol
2'-Brom-2-hydroxy-diaethylaether
2-(2-Bromoethoxy)benzenecarbaldehyde
2-(2-Brom-aethoxy)-aethanol
2-(2-Brom-aethoxy)-benzaldehyd
o-(2-bromoethoxy)benzaldehyde
2-(2-bromo-ethoxy)-benzaldehyde
2<(1-formyl-2-phenyl)oxy>ethylbromide
2-bromoethoxyethanol
Bromo-PEG2-alcohol
Description Bromo-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Density 1.514±0.06 g/cm3
Boiling Point 228.9±15.0 °C
Molecular Formula C4H9BrO2
Molecular Weight 169.01700
Exact Mass 167.97900
PSA 29.46000
LogP 0.39020
Hazard Codes C
111-46-6 structure

111-46-6

~63%

57641-66-4 structure

57641-66-4

Literature: An, Haoyun; Bradshaw, Jerald S.; Krakowiak, Krzysztof E.; Tarbet, Bryon J.; Dalley, N. Kent; et al. Journal of Organic Chemistry, 1993 , vol. 58, # 27 p. 7694 - 7699
75-21-8 structure

75-21-8

540-51-2 structure

540-51-2

~%

57641-66-4 structure

57641-66-4

Literature: DE670419 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 25, p. 865
75-21-8 structure

75-21-8

540-51-2 structure

540-51-2

~%

57641-67-5 structure

57641-67-5

57641-66-4 structure

57641-66-4

Literature: DE670419 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 25, p. 867
107-21-1 structure

107-21-1

106-93-4 structure

106-93-4

~%

57641-66-4 structure

57641-66-4

Literature: Annales de Chimie (Cachan, France), , vol. <3>67, p. 272
107-21-1 structure

107-21-1

106-93-4 structure

106-93-4

~%

123-91-1 structure

123-91-1

57641-67-5 structure

57641-67-5

Detail
Literature: Annales de Chimie (Cachan, France), , vol. <3>67, p. 272
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