Bromo-PEG2-bromide

Names

[ CAS No. ]:
31255-10-4

[ Name ]:
Bromo-PEG2-bromide

[Synonym ]:
AmbotzPEG1075
1,8-dibromo-3,6-dioxaoctane
triethylene glycol dibromide
1,8-dibromo-4,7-dioxaoctane

Biological Activity

[Description]:

Bromo-PEG2-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Chen TH, et al. Metal-organic frameworks constructed from crown ether-based 1,4-benzenedicarboxylic acid derivatives. Dalton Trans. 2016 Feb 21;45(7):3063-9.

Chemical & Physical Properties

[ Density]:
1.655 g/cm3

[ Boiling Point ]:
285.1ºC at 760 mmHg

[ Molecular Formula ]:
C₆H₁₂Br₂O₂

[ Molecular Weight ]:
275.96600

[ Flash Point ]:
113.8ºC

[ Exact Mass ]:
273.92000

[ PSA ]:
18.46000

[ LogP ]:
1.80940

[ Storage condition ]:
2-8°C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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