EGTA

Modify Date: 2024-01-02 17:04:19

EGTA structure	Common Name	EGTA
	CAS Number	67-42-5	Molecular Weight	380.348
	Density	1.4±0.1 g/cm3	Boiling Point	678.0±55.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₂₄N₂O₁₀	Melting Point	241 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	363.9±31.5 °C

Use of EGTA

EGTA is a specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM). EGTA significantly inhibited the substrate adherence capacity of inflammatory macrophages[1][2].

Name	ethylene glycol bis(2-aminoethyl)tetraacetic acid
Synonym	More Synonyms

Description	EGTA is a specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM). EGTA significantly inhibited the substrate adherence capacity of inflammatory macrophages[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	EGTA, proposed as endodontic irrigant, decreases substrate adherence capacity of inflammatory macrophages in a time- and dose-dependent manner. The EGTA concentration that causes an IC50 is 202 mM. Chelators react with calcium ions in the hydroxyapatite crystals to produce a metallic chelate. Removal of calcium ions from the dentine makes the dentinal tissue softer, especially the hydroxyapatite-rich peritubular dentin and increases the diameter of exposed dentinal tubules[2].
References	[1]. Harris RA, Hanrahan JW. Effects of EGTA on calcium signaling in airway epithelial cells. Am J Physiol. 1994;267(5 Pt 1):C1426-C1434. doi:10.1152/ajpcell.1994.267.5.C1426 [2]. Segura-Egea JJ, Jiménez-Rubio A, Rios-Santos JV, Velasco-Ortega E, Calvo-Gutierrez JR. In vitro inhibitory effect of EGTA on macrophage adhesion: endodontic implications. J Endod. 2003;29(3):211-213.

Density	1.4±0.1 g/cm3
Boiling Point	678.0±55.0 °C at 760 mmHg
Melting Point	241 °C (dec.)(lit.)
Molecular Formula	C₁₄H₂₄N₂O₁₀
Molecular Weight	380.348
Flash Point	363.9±31.5 °C
Exact Mass	380.143097
PSA	174.14000
LogP	-2.53
Vapour Pressure	0.0±4.5 mmHg at 25°C
Index of Refraction	1.547
Storage condition	Store at RT.
Water Solubility	slightly soluble

EGTA MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AH3760000

CHEMICAL NAME :: Acetic acid, (ethylenebis(oxyethylenenitrilo))tetra-

CAS REGISTRY NUMBER :: 67-42-5

BEILSTEIN REFERENCE NO. :: 1717370

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C14-H24-N2-O10

MOLECULAR WEIGHT :: 380.40

WISWESSER LINE NOTATION :: QV1N1VQ2O2O2N1VQ1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3587 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 16,807,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84753 No. of Facilities: 111 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 664 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84753 No. of Facilities: 103 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 1556 (estimated) No. of Female Employees: 1043 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	AH3760000
HS Code	29225000

ethylene glycol...

CAS#:929-59-9

Chloroacetic acid

CAS#:79-11-8

EGTA

CAS#:67-42-5

Literature: US2709178 , ;

Precursor 2
CAS#:929-59-9 ethylene glycol... CAS#:79-11-8 Chloroacetic acid
DownStream 0

HS Code	29225000

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Egtazic acid

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Ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid

EGTA

AEGT

ethylene glycol bis(2-aminoethyl)tetraacetic acid

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Ethylene glycol bis(2-aminoethyl ether)tetraacetic acid

EINECS 200-651-2

Ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid

Ethylenebis(oxyethylenenitrilo)tetraacetic acid

MFCD00004291

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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: EGTA
Price: ￥928.0/500g ￥248.0/100g ￥88.0/25g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Ethylenebis(oxyethylenenitrilo)tetraacetic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: ethylene glycol bis(2-aminoethyl)tetraacetic acid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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EGTA

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