99590-86-0

99590-86-0 structure

Name: EGTA-AM
Chemical Name: acetyloxymethyl 2-[[2-(acetyloxymethoxy)-2-oxoethyl]-[2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]ethoxy]ethoxy]ethyl]amino]acetate
CAS Number: 99590-86-0
Molecular Formula: C₂₆H₄₀N₂O₁₈
Molecular Weight: 668.59800
Catalog: Biochemical Assay Reagents
Create Date: 2019-01-04 17:52:22
Modify Date: 2025-08-25 11:31:43
EGTA-AM is a membrane permeable form of EGTA, can be passively loaded into cells to generate intracellular EGTA; EGTA-AM is also a Ca2+ chelator with slow chelating dynamics.

Name	acetyloxymethyl 2-[[2-(acetyloxymethoxy)-2-oxoethyl]-[2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]ethoxy]ethoxy]ethyl]amino]acetate
Synonyms	EGTA acetoxymethyl ester Egta-AME EGTA/AM EGTA-AM

Description	EGTA-AM is a membrane permeable form of EGTA, can be passively loaded into cells to generate intracellular EGTA; EGTA-AM is also a Ca2+ chelator with slow chelating dynamics.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease Biochemical Assay Reagents
In Vitro	EGTA-AM (50 μM) markedly reduces the asynchronous excitatory postsynaptic currents (aEPSC) to 58.9 ± 8.1% of the control level, but only reduces the synchronous excitatory postsynaptic currents (EPSCs), measured as charge transfer produced by the stimulation train[1].
References	[1]. Li MJ, et al. Cholinergic and glutamatergic transmission at synapses between pedunculopotine tegmental nucleus axonal terminals and A7 catecholamine cell group noradrenergic neurons in the rat. Neuropharmacology. 2016 Nov;110(Pt A):237-50