EGTA-AM

Modify Date: 2024-01-05 10:19:39

EGTA-AM Structure
EGTA-AM structure
Common Name EGTA-AM
CAS Number 99590-86-0 Molecular Weight 668.59800
Density 1.303g/cm3 Boiling Point 664.2ºC at 760 mmHg
Molecular Formula C26H40N2O18 Melting Point N/A
MSDS N/A Flash Point 355.5ºC

 Use of EGTA-AM


EGTA-​AM is a membrane permeable form of EGTA, can be passively loaded into cells to generate intracellular EGTA; EGTA-​AM is also a Ca2+ chelator with slow chelating dynamics.

 Names

Name acetyloxymethyl 2-[[2-(acetyloxymethoxy)-2-oxoethyl]-[2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]ethoxy]ethoxy]ethyl]amino]acetate
Synonym More Synonyms

 EGTA-AM Biological Activity

Description EGTA-​AM is a membrane permeable form of EGTA, can be passively loaded into cells to generate intracellular EGTA; EGTA-​AM is also a Ca2+ chelator with slow chelating dynamics.
Related Catalog
In Vitro EGTA-AM (50 μM) markedly reduces the asynchronous excitatory postsynaptic currents (aEPSC) to 58.9 ± 8.1% of the control level, but only reduces the synchronous excitatory postsynaptic currents (EPSCs), measured as charge transfer produced by the stimulation train[1].
References

[1]. Li MJ, et al. Cholinergic and glutamatergic transmission at synapses between pedunculopotine tegmental nucleus axonal terminals and A7 catecholamine cell group noradrenergic neurons in the rat. Neuropharmacology. 2016 Nov;110(Pt A):237-50

 Chemical & Physical Properties

Density 1.303g/cm3
Boiling Point 664.2ºC at 760 mmHg
Molecular Formula C26H40N2O18
Molecular Weight 668.59800
Flash Point 355.5ºC
Exact Mass 668.22800
PSA 235.34000
Index of Refraction 1.487

 Synonyms

EGTA acetoxymethyl ester
Egta-AME
EGTA/AM
EGTA-AM