67-42-5

67-42-5 structure

Name: EGTA
Chemical Name: ethylene glycol bis(2-aminoethyl)tetraacetic acid
CAS Number: 67-42-5
Molecular Formula: C₁₄H₂₄N₂O₁₀
Molecular Weight: 380.348
Catalog: analytical chemistry Standard Titration standard
Create Date: 2018-07-03 14:38:21
Modify Date: 2024-01-02 17:04:19
EGTA is a specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM). EGTA significantly inhibited the substrate adherence capacity of inflammatory macrophages[1][2].

Name	ethylene glycol bis(2-aminoethyl)tetraacetic acid
Synonyms	Egtazic acid ethylene glycol bis(β-aminoethyl ether)-N,N,N',N'-tetraacetic acid Egtazic 4F 4PP oxalate CHEL-DE Ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid EGTA AEGT ethylene glycol bis(2-aminoethyl)tetraacetic acid (Ethylenebis(oxyethylenenitrilo))tetraacetic acid Ethylene glycol bis(2-aminoethyl ether)tetraacetic acid EINECS 200-651-2 Ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid Ethylenebis(oxyethylenenitrilo)tetraacetic acid MFCD00004291 3,12-Bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecane-1,14-dioic acid chel tm-de GIETA [ethylenebis(oxyethylenenitrilo)]tetraacetic acid 6,9-Dioxa-3,12-diazatetradecanedioic acid, 3,12-bis(carboxymethyl)- GEDTA ebonta 3,6-dioxaoctamethylenedinitrilotetraacetic acid

Description	EGTA is a specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM). EGTA significantly inhibited the substrate adherence capacity of inflammatory macrophages[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	EGTA, proposed as endodontic irrigant, decreases substrate adherence capacity of inflammatory macrophages in a time- and dose-dependent manner. The EGTA concentration that causes an IC50 is 202 mM. Chelators react with calcium ions in the hydroxyapatite crystals to produce a metallic chelate. Removal of calcium ions from the dentine makes the dentinal tissue softer, especially the hydroxyapatite-rich peritubular dentin and increases the diameter of exposed dentinal tubules[2].
References	[1]. Harris RA, Hanrahan JW. Effects of EGTA on calcium signaling in airway epithelial cells. Am J Physiol. 1994;267(5 Pt 1):C1426-C1434. doi:10.1152/ajpcell.1994.267.5.C1426 [2]. Segura-Egea JJ, Jiménez-Rubio A, Rios-Santos JV, Velasco-Ortega E, Calvo-Gutierrez JR. In vitro inhibitory effect of EGTA on macrophage adhesion: endodontic implications. J Endod. 2003;29(3):211-213.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 16,807,1970

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84753 No. of Facilities: 111 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 664 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84753 No. of Facilities: 103 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 1556 (estimated) No. of Female Employees: 1043 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	AH3760000
HS Code	29225000

929-59-9

79-11-8

67-42-5

Literature: US2709178 , ;

Precursor 2
929-59-9 79-11-8
DownStream 0

HS Code	29225000