Bromoacetamido-PEG4-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1].
N-Boc-N-bis(PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM[1].
BDP FL-PEG5-acid is a BDP FL acid linker containing a hydrophilic PEG spacer arm. BDP FL-PEG5-acid can be used in the synthesis of PROTACs. BDP FL is a green-fluorescent dye, and the hydrophilic PEG spacer arm increases water solubility and membrane permability.
N-Boc-piperazine is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183)[1].
N,N'-bis-(azide-PEG3)-chlorocyclohexenyl Cy7 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Azido-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Gly-PEG3-endo-BCN is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Hydroxy-PEG3-acrylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Methyl-PEG4-acyl chloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Mal-C2-cyclohexylcarboxyl-hydrazide (TFA) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Thalidomide-O-amido-C4-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].
Pomalidomide-C11-NH2 is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-C11-NH2 can be connected to the ligand for protein by a linker to form PROTAC[1].
Mal-amido-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
E3 ligase Ligand 3 is a ligand of E3 ligase, used in PROTAC technology.
Fmoc-NH-PEG12-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
TCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
（S,R,S)-AHPC-CO-CI-Br is a novel protac building block,
CMP98, a PROTAC, is unable to induce degradation of VHL. CMP98 can be used as a negative control compound for CM11[1].
Boc-NH-PEG15-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
C-NH-Boc-C-Bis-(C1-PEG1-PFP) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Biotin-PEG2-C6-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
m-PEG12-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Boc-NH-PEG11-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
N-(Boc-PEG5)-N-bis(PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Thalidomide-5-O-CH2-COOH is an E3 Ligase Ligand-Linker Conjugate consisting of Thalidomide (HY-14658) and NH-PEG3-NH-Boc. Thalidomide-5-O-CH2-COOH acts as a ligand for Cereblon to recruit CRBN protein. Thalidomide-5-O-CH2-COOH is a key intermediate in the synthesis of PROTAC molecules designed based on CRBN.
Boc-NH-PEG12-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
A031 is a highly effective PROTAC androgen receptor (AR) degrader with an IC50 value less than 0.25 μM for AR protein degradation. A031 has an inhibitory effect on tumor growth in zebrafish with human prostate cancer (VCaP)[1].
Thalidomide-NH-PEG3-propionic acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology[1].
JH-XI-10-02 is a potent and selective degrader of CDK8, with an IC50 of 159 nM, based on PROTAC. JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19[1].