SJF620
Modify Date: 2025-08-27 10:52:25
SJF620 structure
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Common Name | SJF620 | ||
|---|---|---|---|---|
| CAS Number | 2376187-16-3 | Molecular Weight | 760.84 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C41H44N8O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SJF620SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM[1]. |
| Name | SJF620 |
|---|
| Description | SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM[1]. |
|---|---|
| Related Catalog | |
| Target |
Cereblon |
| In Vitro | SJF620 is a PROTAC that retains potent degradation of BTK in cellular assays with a DC50 of 7.9 nM in NAMALWA cells line[1]. |
| In Vivo | SJF620 has a super pharmacokinetic profile in mice (1 mg/kg; i.v.) with half life (t1/2) of 1.64 h. SJF620 exhibits a significantly better pharmacokinetic profile than MT802[1]. |
| References |
| Molecular Formula | C41H44N8O7 |
|---|---|
| Molecular Weight | 760.84 |
| Storage condition | -20°C |