SJF620

Names

[ CAS No. ]:
2376187-16-3

[ Name ]:
SJF620

Biological Activity

[Description]:

SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk

Signaling Pathways >> PROTAC >> PROTAC

[Target]

Cereblon

[In Vitro]

SJF620 is a PROTAC that retains potent degradation of BTK in cellular assays with a DC50 of 7.9 nM in NAMALWA cells line[1].

[In Vivo]

SJF620 has a super pharmacokinetic profile in mice (1 mg/kg; i.v.) with half life (t1/2) of 1.64 h. SJF620 exhibits a significantly better pharmacokinetic profile than MT802[1].

[References]

[1]. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₁H₄₄N₈O₇

[ Molecular Weight ]:
760.84

[ Storage condition ]:
-20°C

Related Compounds

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