HO-PEG21-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Mal-amido-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Mal-PFP ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
m-PEG5-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
m-PEG9-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Fmoc-NH-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Thalidomide-Piperazine-Piperidine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
N-(Hydroxy-PEG3)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
N-(m-PEG4)-N'-(azide-PEG4)-Cy3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Amino-PEG5-amine is a PEG-based (5 units) PROTAC linker can be used in the synthesis of PROTACs.
Pomalidomide-PEG6-butyl iodide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 6-unit PEG linker used in PROTAC technology[1].
(S,R,S)-AHPC-amido-C5-acid incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design XY028-133 (HY-129180)[1].
Fmoc-NMe-PEG4-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Boc-PEG4-C2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
KB02-JQ1 is a highly selective and PROTAC-based BRD4 degrader (molecular glue), but does not degrade BRD2 or BRD3. KB02-JQ1 promotes BRD4 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. JQ1 binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-JQ1[1].
AD4 is an artemisinin derivative that is a proteolytic targeting chimera (PROTAC) targeting PCLAF. AD4 can effectively degrade PCLAF in RS4;11 cells (IC50: 0.6 nM), thereby activating the p21/Rb axis and exerting anti-tumor activity. AD4 also prolonged survival of RS4;11-transplanted NOD/SCID mice, with in vivo efficacy[1].
Mal-NH-PEG4-CH2CH2COOPFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Thalidomide-O-C6-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
Bis-Tos-PEG6 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
TGN-020 sodium is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 μM[1][2]. TGN-020 sodium is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[3]. TGN-020 sodium alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats[4].
Tetrazine-Ph-NHCO-C3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Benzyl-PEG5-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Cbz-PEG2-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTAC BRD4 Degrader-3 (compound 1004.1) is an efficacious PROTAC BRD4 degrader[1].
m-PEG8-CH2CH2-NHS ester is a PEG--based PROTAC linker can be used in the synthesis of PROTACs.
Cbz-NH-PEG1-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
m-PEG7-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
111-Trifluoroethyl-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
N-Me-N-bis(PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Nonylbenzene-PEG8-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].