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65883-12-7

65883-12-7 structure
65883-12-7 structure
  • Name: PEG4-Ms
  • Chemical Name: 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl methanesulfonate
  • CAS Number: 65883-12-7
  • Molecular Formula: C9H20O7S
  • Molecular Weight: 272.31600
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2017-12-19 03:26:52
  • Modify Date: 2024-01-10 15:21:43
  • PEG4-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl methanesulfonate
Synonyms 3,6,9,12-Tetraoxa-2-thiatetradecan-14-ol,2,2-dioxide
2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethyl methanesulfonate
11-[(methylsulfonyl)oxy]-3,6,9-trioxaundecanol
Description PEG4-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula C9H20O7S
Molecular Weight 272.31600
Exact Mass 272.09300
PSA 99.67000
LogP 0.08550

~79%

65883-12-7 structure

65883-12-7

Literature: Zemlyakov; Kur'yanov; Sidorova; Chupakina; Chirva Chemistry of Natural Compounds, 1997 , vol. 33, # 5 p. 563 - 567

~61%

65883-12-7 structure

65883-12-7

Literature: Svedhem; Hollander; Shi; Konradsson; Liedberg; Svensson Journal of Organic Chemistry, 2001 , vol. 66, # 13 p. 4494 - 4503

~%

65883-12-7 structure

65883-12-7

Literature: Jalisatgi, Satish S.; Kulkarni, Vikas S.; Tang, Betty; Houston, Zachary H.; Lee, Mark W.; Hawthorne, M. Frederick Journal of the American Chemical Society, 2011 , vol. 133, # 32 p. 12382 - 12385

~%

65883-12-7 structure

65883-12-7

Literature: Jalisatgi, Satish S.; Kulkarni, Vikas S.; Tang, Betty; Houston, Zachary H.; Lee, Mark W.; Hawthorne, M. Frederick Journal of the American Chemical Society, 2011 , vol. 133, # 32 p. 12382 - 12385

~%

65883-12-7 structure

65883-12-7

Literature: Jalisatgi, Satish S.; Kulkarni, Vikas S.; Tang, Betty; Houston, Zachary H.; Lee, Mark W.; Hawthorne, M. Frederick Journal of the American Chemical Society, 2011 , vol. 133, # 32 p. 12382 - 12385

~%

65883-12-7 structure

65883-12-7

Literature: Jalisatgi, Satish S.; Kulkarni, Vikas S.; Tang, Betty; Houston, Zachary H.; Lee, Mark W.; Hawthorne, M. Frederick Journal of the American Chemical Society, 2011 , vol. 133, # 32 p. 12382 - 12385

~%

65883-12-7 structure

65883-12-7

Literature: Jalisatgi, Satish S.; Kulkarni, Vikas S.; Tang, Betty; Houston, Zachary H.; Lee, Mark W.; Hawthorne, M. Frederick Journal of the American Chemical Society, 2011 , vol. 133, # 32 p. 12382 - 12385

~%

65883-12-7 structure

65883-12-7

Literature: Jalisatgi, Satish S.; Kulkarni, Vikas S.; Tang, Betty; Houston, Zachary H.; Lee, Mark W.; Hawthorne, M. Frederick Journal of the American Chemical Society, 2011 , vol. 133, # 32 p. 12382 - 12385