2087490-42-2

2087490-42-2 structure

Name: Tz-Thalidomide
Chemical Name: 6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-N-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzyl)hexanamide
CAS Number: 2087490-42-2
Molecular Formula: C₂₉H₂₉N₇O₆
Molecular Weight: 571.58
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2022-11-22 00:47:08
Modify Date: 2024-04-03 18:46:15
Tz-Thalidomide is a tetrazine tagged Thalidomide (HY-14658) (Ligands for E3 Ligase). Tz-Thalidomide has binding affinity for BRD4, with IC50s of 46.25 μM (BRD4-1) and 62.55 μM (BRD4-2)[1].

Name	6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-N-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzyl)hexanamide

Description	Tz-Thalidomide is a tetrazine tagged Thalidomide (HY-14658) (Ligands for E3 Ligase). Tz-Thalidomide has binding affinity for BRD4, with IC50s of 46.25 μM (BRD4-1) and 62.55 μM (BRD4-2)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	46.25 μM (BRD4-1), 62.55 μM (BRD4-2)[1]
References	[1]. Lebraud H, et al. Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras. ACS Cent Sci. 2016 Dec 28;2(12):927-934.

Molecular Formula	C₂₉H₂₉N₇O₆
Molecular Weight	571.58