PROTAC Linker

Total: 1884
Updated: 2019-06-28 15:55:20
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.

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PROTAC >
PROTAC E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase PROTAC Linker PROTAC-linker Conjugate for PAC
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N-(Azido-PEG4)-N-Boc-PEG4-t-butyl ester

N-(Azido-PEG4)-N-Boc-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2112737-20-7
  • MF: C30H58N4O12
  • MW: 666.80
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Tos-PEG9-Tos

Tos-PEG9-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 109635-64-5
  • MF: C32H50O14S2
  • MW: 722.86100
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Bis-aminooxy-PEG2

Bis-aminooxy-PEG2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 98627-71-5
  • MF: C6H16N2O4
  • MW: 180.20
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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DNP-PEG4-DBCO

DNP-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2149585-17-9
  • MF: C35H39N5O10
  • MW: 689.71
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Tosylate of Hexaethylene glycol monobenzyl ether

Benzyl-PEG6-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 129086-11-9
  • MF: C26H38O9S
  • MW: 526.64000
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG10-azide

Azido-PEG10-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1421783-42-7
  • MF: C22H44N6O10
  • MW: 552.62
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,55,58,61,64,67,70,73,76-pentacosaoxa-4-azanonaheptacontan-79-oic acid

Fmoc-N-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2170484-59-8
  • MF: C66H113NO28
  • MW: 1368.59
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N-Mal-N-bis(PEG2-amine) TFA

N-Mal-N-bis(PEG2-amine) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2128735-20-4
  • MF: C19H34N4O7
  • MW: 430.50
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Amino-PEG9-Boc

Amino-PEG9-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1818294-44-8
  • MF: C25H51NO11
  • MW: 541.672
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 576.2±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 91.9±25.0 °C
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BnO-PEG1-CH2CO2tBu

BnO-PEG1-CH2CO2tBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1309451-06-6
  • MF: C15H22O4
  • MW: 266.33300
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG3-amido-C3-triethoxysilane

m-PEG3-amido-C3-triethoxysilane is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 2243566-45-0
  • MF: C17H37NO7Si
  • MW: 395.56
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Br-PEG3-C2-Boc

Br-PEG3-C2-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 782475-37-0
  • MF: C13H25BrO5
  • MW: 341.239
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 375.4±27.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 180.8±23.7 °C
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Carboxy-PEG4-phosphonic acid ethyl ester

Carboxy-PEG4-phosphonic acid ethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1964503-39-6
  • MF: C15H31O9P
  • MW: 386.38
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Hydroxy-PEG2-acid

Hydroxy-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1334286-77-9
  • MF: C7H14O5
  • MW: 178.18306
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N-(acid-PEG3)-N-bis(PEG3-azide)

N-(acid-PEG3)-N-bis(PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2182602-17-9
  • MF: C25H49N7O11
  • MW: 623.70
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Benzyl-PEG5-Ots

Benzyl-PEG5-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 129086-10-8
  • MF: C24H34O8S
  • MW: 482.59
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Bis-aminooxy-PEG4

Bis-aminooxy-PEG4 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 98627-72-6
  • MF: C10H24N2O6
  • MW: 268.31
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Hydroxy-PEG3-acid

Hydroxy-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 518044-49-0
  • MF: C9H18O6
  • MW: 266.288
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 420.7±40.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 155.5±20.8 °C
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Mal-PEG3-NH2 TFA

Mal-PEG3-NH2 TFA is a linear heterobifunctional PEG crosslinker with Maleimide (HY-W007324) and amine. Mal-PEG3-NH2 TFA is a non-degradable (non-cleavable) PROTAC linker[1].

  • CAS Number: 2830214-77-0
  • MF: C14H21F3N2O7
  • MW: 386.32
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azide-PEG6-Tos

Azide-PEG6-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 906007-10-1
  • MF: C19H31N3O8S
  • MW: 461.53
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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endo-BCN-PEG3-NHS ester

endo-BCN-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2101206-94-2
  • MF: C24H34N2O9
  • MW: 494.53
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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1-benzyloxycarbonylazetidine-3-carboxylic acid

1-Cbz-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Cbz-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]

  • CAS Number: 97628-92-7
  • MF: C12H13NO4
  • MW: 235.236
  • Catalog: ADC Linker
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 421.2±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 208.5±28.7 °C
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Benzyl(S)-11-benzyl-1-(9H-fluoren-9-yl)-3,6,9,12,15-pentaoxo-2,18-dioxa-4,7,10,13,16-pentaazaicosan-20-oate

Fmoc-Gly-Gly-Phe-Gly-CH2-O-CH2-Cbz is a PROTAC linker and a maleimide-GGFG peptide linker. Fmoc-Gly-Gly-Phe-Gly-CH2-O-CH2-Cbz can be used in the synthesis of the Deruxtecan[1].

  • CAS Number: 2264011-97-2
  • MF: C40H41N5O9
  • MW: 735.78
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG12-amine

m-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG12-amine is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

  • CAS Number: 1977493-48-3
  • MF: C25H53NO12
  • MW: 559.688
  • Catalog: ADC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 583.6±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 291.3±22.4 °C
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BnO-PEG5-Boc

BnO-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1807537-31-0
  • MF: C23H38O8
  • MW: 442.543
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 507.3±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 214.4±28.8 °C
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Aminooxy-PEG3-NH-Boc

Aminooxy-PEG3-C2-NH-Boc is a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2062663-65-2
  • MF: C13H28N2O6
  • MW: 308.37
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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DBCO-PEG4-acid

DBCO-PEG4-acid is a a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2110448-99-0
  • MF: C30H36N2O8
  • MW: 552.62
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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t-Butoxycarbonyl-PEG5-sulfonic acid

Butoxycarbonyl-PEG5-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1817735-28-6
  • MF: C17H34O10S
  • MW: 430.51
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N-(Biotin)-N-bis(PEG1-alcohol)

N-(Biotin)-N-bis(PEG1-alcohol) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2100306-75-8
  • MF: C18H33N3O6S
  • MW: 419.54
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG3-phosphonic acid

m-PEG3-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 96962-42-4
  • MF: C7H17O6P
  • MW: 228.18000
  • Catalog: PROTAC Linker
  • Density: 1.251±0.06 g/cm3(20 °C , 760mmHg)
  • Boiling Point: 382.9±50.0 °C (760 mmHg)
  • Melting Point: N/A
  • Flash Point: N/A
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