1977493-48-3

1977493-48-3 structure

Name: m-PEG12-amine
Chemical Name: MPEG12-NH2
CAS Number: 1977493-48-3
Molecular Formula: C₂₅H₅₃NO₁₂
Molecular Weight: 559.688
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2018-12-18 09:49:16
Modify Date: 2025-08-21 11:50:38
m-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG12-amine is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

Name	MPEG12-NH2
Synonyms	2,5,8,11,14,17,20,23,26,29,32,35-Dodecaoxaheptatriacontan-37-amine m-dPEG(R)12-amine MFCD11041151

Description	m-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG12-amine is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Non-cleavable
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
References	[1]. Vasco AV, et al. A Multicomponent Stapling Approach to Exocyclic Functionalized Helical Peptides: Adding Lipids, Sugars, PEGs, Labels, and Handles to the Lactam Bridge. Bioconjug Chem. 2019 Jan 16;30(1):253-259. [2]. Joseph Fox, et al. Methods for inducing bioorthogonal reactivity. WO2017106427A1.