PROTAC Linker

Total: 1884
Updated: 2019-06-28 15:55:20
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.

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PROTAC >
PROTAC E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase PROTAC Linker PROTAC-linker Conjugate for PAC
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2-(2-((tert-Butoxycarbonyl)amino)ethoxy)ethyl 4-methylbenzenesulfonate

Tos-PEG2-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 192132-77-7
  • MF: C16H25NO6S
  • MW: 359.44
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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THP-PEG9

THP-PEG8-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 658858-65-2
  • MF: C21H42O10
  • MW: 454.55
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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DBCO-C-PEG1

DBCO-C-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2377004-09-4
  • MF: C22H22N2O3
  • MW: 362.42
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Aminoethyl-SS-ethylalcohol

Aminoethyl-SS-ethylalcohol (Compound 3) is an Alkyl-Chain-based PROTAC linker can be used in the synthesis of PROTACs[1]. Aminoethyl-SS-ethylalcohol is also a glutathione cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

  • CAS Number: 15579-01-8
  • MF: C4H11NOS2
  • MW: 153.27
  • Catalog: ADC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N-(Boc-PEG3)-N-bis(PEG3-acid)

N-(Boc-PEG3)-N-bis(PEG3-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2055042-61-8
  • MF: C31H60N2O15
  • MW: 700.81
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG3-S-Acetyl

m-PEG3-S-Acetyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 857284-78-7
  • MF: C9H18O4S
  • MW: 222.30200
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Carboxyrhodamine 110-PEG3-Azide

Carboxyrhodamine 110-PEG3-Azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1536327-95-3
  • MF: C58H60N12O14
  • MW: 574.6
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG5-CH2CO2-NHS

Azido-PEG5-CH2CO2-NHS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2144777-77-3
  • MF: C16H26N4O9
  • MW: 418.40
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Tos-PEG4-Boc

Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker, which refers to the PEG composition. Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) can be used in the synthesis of a series of PROTACs, such as BI-3663 (HY-111546). BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation, and inhibits PTK2 with an IC50 of 18 nM[1].

  • CAS Number: 217817-01-1
  • MF: C20H32O8S
  • MW: 432.528
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 528.5±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 273.4±28.7 °C
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NHS-PEG4-(m-PEG4)3-ester

NHS-PEG4-(m-PEG4)3-ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1333154-70-3
  • MF: C60H110N6O28
  • MW: 1363.539
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG4-azide

m-PEG4-azide (13-Azido-2,5,8,11-tetraoxatridecane) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 606130-90-9
  • MF: C9H19N3O4
  • MW: 233.26500
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Bromo-PEG1-CH2COOH

Bromo-PEG1-CH2COOH is a PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 1135131-50-8
  • MF: C4H7BrO3
  • MW: 183.001
  • Catalog: PROTAC Linker
  • Density: 1.7±0.1 g/cm3
  • Boiling Point: 316.4±17.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 145.2±20.9 °C
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Propargyl-PEG5-Br

Propargyl-PEG5-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1287660-83-6
  • MF: C13H23BrO5
  • MW: 339.22
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Benzyl-PEG1-propanol

Benzyl-PEG1-propanol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 131326-24-4
  • MF: C12H18O3
  • MW: 210.27
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Boc-NH-PEG2-CH2COOH

Boc-NH-PEG2-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 108466-89-3
  • MF: C11H21NO6
  • MW: 263.28800
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: 630.4°C
  • Melting Point: 240°C
  • Flash Point: N/A
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Aminooxy-PEG5-azide

Aminooxy-PEG5-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 1919045-02-5
  • MF: C12H26N4O6
  • MW: 322.36
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Cbz-NH-PEG12-C2-acid

Cbz-NH-PEG12-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1334177-88-6
  • MF: C35H61NO16
  • MW: 751.85594
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Methyl propionate-PEG12

Methyl propionate-PEG12 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1239588-11-4
  • MF: C28H56O15
  • MW: 632.735
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 646.1±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 190.2±23.6 °C
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m-PEG10-acid

m-PEG10-acid is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG10-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

  • CAS Number: 2409969-94-2
  • MF: C22H44O12
  • MW: 500.58
  • Catalog: ADC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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DSPE-PEG4-DBCO

DSPE-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2112738-14-2
  • MF: C71H116N3O15P
  • MW: 1282.67
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Methyltetrazine-PEG8-PFP ester

Methyltetrazine-PEG8-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2353409-49-9
  • MF: C34H43F5N4O11
  • MW: 778.72
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Propargyl-PEG2-Ms

Propargyl-PEG2-Ms is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 943726-01-0
  • MF: C8H14O5S
  • MW: 222.259
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 358.0±27.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 170.3±23.7 °C
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m-PEG5-SH

m-PEG5-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 524030-00-0
  • MF: C11H24O5S
  • MW: 268.37000
  • Catalog: PROTAC Linker
  • Density: 1.048
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N-(Amino-PEG3)-N-bis(PEG3-t-butyl ester) HCl

N-(Amino-PEG3)-N-bis(PEG3-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2055042-62-9
  • MF: C34H68N2O13
  • MW: 712.91
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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PEG2-Cl

PEG2-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 78925-46-9
  • MF: C5H11ClO2
  • MW: 138.593
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 236.9±15.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 97.1±20.4 °C
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Thiol-C9-PEG5

Thiol-C9-PEG5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 130727-42-3
  • MF: C19H40O5S
  • MW: 380.58300
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid

N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2183440-74-4
  • MF: C29H55N5O13
  • MW: 681.77
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG12-2-methylacrylate

Propargyl-PEG13-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2867-46-1
  • MF: C29H56O14
  • MW: 628.75
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Benzyl-PEG8-THP

Benzyl-PEG8-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1611489-00-9
  • MF: C28H48O10
  • MW: 544.675
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 602.0±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 224.1±31.4 °C
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1,1,1-Trifluoroethyl-PEG4-aminooxy

1,1,1-Trifluoroethyl-PEG4-aminooxy is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1895922-78-7
  • MF: C10H20F3NO5
  • MW: 291.26
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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