Benzyl-PEG8-THP

Modify Date: 2024-01-08 09:19:58

Benzyl-PEG8-THP Structure
Benzyl-PEG8-THP structure
Common Name Benzyl-PEG8-THP
CAS Number 1611489-00-9 Molecular Weight 544.675
Density 1.1±0.1 g/cm3 Boiling Point 602.0±55.0 °C at 760 mmHg
Molecular Formula C28H48O10 Melting Point N/A
MSDS N/A Flash Point 224.1±31.4 °C

 Use of Benzyl-PEG8-THP


Benzyl-PEG8-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[(1-Phenyl-2,5,8,11,14,17,20,23-octaoxapentacosan-25-yl)oxy]tetrahydro-2H-pyran
Synonym More Synonyms

 Benzyl-PEG8-THP Biological Activity

Description Benzyl-PEG8-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 602.0±55.0 °C at 760 mmHg
Molecular Formula C28H48O10
Molecular Weight 544.675
Flash Point 224.1±31.4 °C
Exact Mass 544.324768
LogP -0.48
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.499

 Synonyms

MFCD29049395
2-[(1-Phenyl-2,5,8,11,14,17,20,23-octaoxapentacosan-25-yl)oxy]tetrahydro-2H-pyran
2H-Pyran, tetrahydro-2-[(25-phenyl-3,6,9,12,15,18,21,24-octaoxapentacos-1-yl)oxy]-
Benzyl-PEG8-THP