477775-73-8

477775-73-8 structure

Name: Benzyl-PEG8-alcohol
Chemical Name: 2-[2-[2-[2-[2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
CAS Number: 477775-73-8
Molecular Formula: C₂₃H₄₀O₉
Molecular Weight: 460.55800
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2017-06-01 06:59:00
Modify Date: 2024-01-11 17:33:45
Benzyl-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-[2-[2-[2-[2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Synonyms	1-phenyl-2,5,8,11,14,17,20,23-octaoxapenta-cosan-25-ol octaethylene glycol monobenzyl ether

Description	Benzyl-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562