Benzyl-PEG8-alcohol

Modify Date: 2024-01-11 17:33:45

Benzyl-PEG8-alcohol Structure
Benzyl-PEG8-alcohol structure
Common Name Benzyl-PEG8-alcohol
CAS Number 477775-73-8 Molecular Weight 460.55800
Density N/A Boiling Point N/A
Molecular Formula C23H40O9 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Benzyl-PEG8-alcohol


Benzyl-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-[2-[2-[2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Synonym More Synonyms

 Benzyl-PEG8-alcohol Biological Activity

Description Benzyl-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C23H40O9
Molecular Weight 460.55800
Exact Mass 460.26700
PSA 94.07000
LogP 1.31170

 Synthetic Route

 Synonyms

1-phenyl-2,5,8,11,14,17,20,23-octaoxapenta-cosan-25-ol
octaethylene glycol monobenzyl ether