524030-00-0

524030-00-0 structure

Name: m-PEG5-SH
Chemical Name: 2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethanethiol
CAS Number: 524030-00-0
Molecular Formula: C₁₁H₂₄O₅S
Molecular Weight: 268.37000
Catalog: Chemical reagent Organic reagent Thiol salt
Create Date: 2018-12-25 10:16:57
Modify Date: 2024-01-08 21:19:09
m-PEG5-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethanethiol
Synonyms	3,6,9,12,15-pentaoxahexadecane-1-thiol

Description	m-PEG5-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562