PROTAC Linker

Total: 1884
Updated: 2019-06-28 15:55:20
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.

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PI3K/Akt/mTOR >
Akt AMPK ATM/ATR DNA-PK GSK-3 MELK mTOR PDK-1 PI3K PI4K PIKfyve PTEN
PROTAC >
PROTAC E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase PROTAC Linker PROTAC-linker Conjugate for PAC
Protein Tyrosine Kinase/RTK >
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1-(4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenoxy)-N-(3-(triethoxysilyl)propyl)-3,6,9,12-tetraoxapentadecan-15-amide

Methyltetrazine-PEG5-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2353410-01-0
  • MF: C29H49N5O9Si
  • MW: 639.81
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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TCO-PNB ester

TCO-PNB ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1438415-89-4
  • MF: C15H17NO5
  • MW: 291.30
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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SLc-nhs-(+)-biotin

Biotin-C10-NHS Ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 887628-40-2
  • MF: C25H40N4O6S
  • MW: 524.67
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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endo-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (15-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-13-oxo-3,6,9-trioxa-12-azapentadecyl)carbamate

endo-BCN-PEG3-mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2141976-33-0
  • MF: C26H37N3O8
  • MW: 519.59
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N-Mal-N-bis(PEG4-NHS ester)

N-Mal-N-bis(PEG4-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2112738-60-8
  • MF: C37H54N4O19
  • MW: 858.84
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N-Desthiobiotin-N-bis(PEG4-t-butyl ester)

N-Desthiobiotin-N-bis(PEG4-t-butyl ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2353409-60-4
  • MF: C40H75N3O14
  • MW: 822.04
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Chloroacetamido-PEG4-C2-Boc

Chloroacetamido-PEG4-C2-Boc is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 1365655-90-8
  • MF: C17H32ClNO7
  • MW: 397.892
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 527.7±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 272.9±30.1 °C
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PEG3-bis(phosphonic acid)

PEG3-bis(phosphonic acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 254762-10-2
  • MF: C8H20O9P2
  • MW: 322.186
  • Catalog: PROTAC Linker
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 588.2±60.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 309.5±32.9 °C
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1-isothiocyanato-PEG4-Alcohol

1-Isothiocyanato-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1835759-69-7
  • MF: C9H17NO4S
  • MW: 235.30
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Benzyl-PEG24-MS

Benzyl-PEG24-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2218463-20-6
  • MF: C56H106O27S
  • MW: 1243.49
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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NH2-PEG7

NH2-PEG7 is a PROTAC linker, which refers to the PEG composition. NH2-PEG7 can be used in the synthesis of the PROTAC PARP1 degrader iRucaparib-AP6[1].

  • CAS Number: 1425973-14-3
  • MF: C14H31NO7
  • MW: 325.398
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 427.3±40.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 212.2±27.3 °C
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Methyltetrazine-PEG4-azide

Methyltetrazine-Ph-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1802908-04-8
  • MF: C17H23N7O4
  • MW: 389.41
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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FmocNH-PEG3-CH2CH2NH2 hydrochloride

FmocNH-PEG3-CH2CH2NH2 (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 906079-91-2
  • MF: C23H31ClN2O5
  • MW: 450.96
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Bis-acrylate-PEG5

Bis-acrylate-PEG5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 59256-52-9
  • MF: C16H26O8
  • MW: 346.37300
  • Catalog: PROTAC Linker
  • Density: 1.098g/cm3
  • Boiling Point: 421.5ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 181.9ºC
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S-acetyl-PEG4-propargyl

S-acetyl-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1422540-88-2
  • MF: C13H22O5S
  • MW: 290.37
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Ms-PEG8-Ms

Ms-PEG7-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 109789-41-5
  • MF: C16H34O12S2
  • MW: 482.56
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Mal-C4-NH-Boc

Mal-C4-NH-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 124529-64-2
  • MF: C15H24N2O4
  • MW: 296.362
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 445.8±28.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 223.4±24.0 °C
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S-acetyl-PEG6-Tos

S-acetyl-PEG6-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1818294-25-5
  • MF: C21H34O9S2
  • MW: 494.619
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 591.0±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 311.2±30.1 °C
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H2N-PEG4-Hydrazide

H2N-PEG4-Hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1425973-15-4
  • MF: C11H25N3O5
  • MW: 279.33
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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t-Boc-Aminooxy-PEG4-CH2CO2H

Boc-Aminooxy-PEG4-CH2CO2H is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2028281-90-3
  • MF: C15H29NO9
  • MW: 367.39
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Hydroxy-PEG2-CH2-Boc

Hydroxy-PEG2-CH2-Boc is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 149299-82-1
  • MF: C10H20O5
  • MW: 220.263
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 306.1±22.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 109.5±15.8 °C
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TCO-PEG8-acid

TCO-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 2353410-03-2
  • MF: C28H51NO12
  • MW: 593.70
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Hydroxy-PEG3-CH2-Boc

Hydroxy-PEG3-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 518044-31-0
  • MF: C12H24O6
  • MW: 264.315
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 351.2±27.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 121.9±17.2 °C
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Tr-PEG4-OH

Tr-PEG4-OH is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

  • CAS Number: 125274-16-0
  • MF: C27H32O5
  • MW: 436.54000
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Methyltetrazine-PEG4-maleimide

Methyltetrazine-PEG4-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1802908-02-6
  • MF: C24H30N6O7
  • MW: 613.662
  • Catalog: PROTAC Linker
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Maleimide-C10-NHS ester

Maleimide-C10-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 87981-04-2
  • MF: C19H26N2O6
  • MW: 378.419
  • Catalog: PROTAC Linker
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 520.4±42.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 268.5±27.9 °C
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N-(m-PEG4)-N'-(PEG4-NHS ester)-Cy5

N-(m-PEG4)-N'-(PEG4-NHS ester)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2107273-30-1
  • MF: C49H68ClN3O12
  • MW: 926.53
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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t-Butoxycarbonyl-PEG2-sulfonic acid

Boc-PEG2-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1817735-40-2
  • MF: C11H22O7S
  • MW: 298.35
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG-OH (MW 2000)

m-PEG-OH (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 9004-74-4
  • MF: C23H48O12
  • MW: 516.620
  • Catalog: PROTAC Linker
  • Density: 1.08
  • Boiling Point: 557.1±45.0 °C at 760 mmHg
  • Melting Point: 12 ºC
  • Flash Point: 268 ºC
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Ald-Ph-PEG5-Boc

Ald-Ph-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1433996-83-8
  • MF: C22H34O8
  • MW: 426.501
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 521.3±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 222.5±30.2 °C
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