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254762-10-2

254762-10-2 structure
254762-10-2 structure
  • Name: PEG3-bis(phosphonic acid)
  • Chemical Name: [Oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis(phosphonic acid)
  • CAS Number: 254762-10-2
  • Molecular Formula: C8H20O9P2
  • Molecular Weight: 322.186
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-23 13:07:35
  • Modify Date: 2024-01-10 19:13:49
  • PEG3-bis(phosphonic acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name [Oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis(phosphonic acid)
Synonyms Phosphonic acid, [oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis-
MFCD00778114
[Oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis(phosphonic acid)
Description PEG3-bis(phosphonic acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.5±0.1 g/cm3
Boiling Point 588.2±60.0 °C at 760 mmHg
Molecular Formula C8H20O9P2
Molecular Weight 322.186
Flash Point 309.5±32.9 °C
Exact Mass 322.058258
LogP -4.65
Vapour Pressure 0.0±3.6 mmHg at 25°C
Index of Refraction 1.501