PEG3-bis(phosphonic acid)

Modify Date: 2025-08-25 10:34:06

PEG3-bis(phosphonic acid) Structure
PEG3-bis(phosphonic acid) structure
Common Name PEG3-bis(phosphonic acid)
CAS Number 254762-10-2 Molecular Weight 322.186
Density 1.5±0.1 g/cm3 Boiling Point 588.2±60.0 °C at 760 mmHg
Molecular Formula C8H20O9P2 Melting Point N/A
MSDS N/A Flash Point 309.5±32.9 °C

 Use of PEG3-bis(phosphonic acid)


PEG3-bis(phosphonic acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name [Oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis(phosphonic acid)
Synonym More Synonyms

 PEG3-bis(phosphonic acid) Biological Activity

Description PEG3-bis(phosphonic acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 588.2±60.0 °C at 760 mmHg
Molecular Formula C8H20O9P2
Molecular Weight 322.186
Flash Point 309.5±32.9 °C
Exact Mass 322.058258
LogP -4.65
Vapour Pressure 0.0±3.6 mmHg at 25°C
Index of Refraction 1.501
InChIKey QSULJYOIONNJQJ-UHFFFAOYSA-N
SMILES O=P(O)(O)CCOCCOCCOCCP(=O)(O)O

 Synonyms

Phosphonic acid, [oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis-
MFCD00778114
[Oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis(phosphonic acid)
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