PEG3-bis-(ethyl phosphonate)

Modify Date: 2024-01-05 23:46:14

PEG3-bis-(ethyl phosphonate) Structure
PEG3-bis-(ethyl phosphonate) structure
Common Name PEG3-bis-(ethyl phosphonate)
CAS Number 160625-24-1 Molecular Weight 434.399
Density 1.1±0.1 g/cm3 Boiling Point 510.5±45.0 °C at 760 mmHg
Molecular Formula C16H36O9P2 Melting Point N/A
MSDS N/A Flash Point 275.6±49.1 °C

 Use of PEG3-bis-(ethyl phosphonate)


PEG3-bis-(ethyl phosphonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Tetraethyl [oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis(phosphonate)
Synonym More Synonyms

 PEG3-bis-(ethyl phosphonate) Biological Activity

Description PEG3-bis-(ethyl phosphonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 510.5±45.0 °C at 760 mmHg
Molecular Formula C16H36O9P2
Molecular Weight 434.399
Flash Point 275.6±49.1 °C
Exact Mass 434.183441
LogP -1.19
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.443

 Synonyms

Tetraethyl [oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis(phosphonate)
MFCD00778113
Phosphonic acid, P,P'-[oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis-, tetraethyl ester