PEG3-bis-(ethyl phosphonate)

Names

[ Name ]:
PEG3-bis-(ethyl phosphonate)

[Synonym ]:
Tetraethyl [oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis(phosphonate)
MFCD00778113
Phosphonic acid, P,P'-[oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis-, tetraethyl ester

Biological Activity

[Description]:

PEG3-bis-(ethyl phosphonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
510.5±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₃₆O₉P₂

[ Molecular Weight ]:
434.399

[ Flash Point ]:
275.6±49.1 °C

[ Exact Mass ]:
434.183441

[ LogP ]:
-1.19

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.443

PEG3-bis-(ethyl phosphonate)

Names

Biological Activity

Chemical & Physical Properties

Related Compounds