Bromo-PEG3-phosphonic acid diethyl ester

Names

[ Name ]:
Bromo-PEG3-phosphonic acid diethyl ester

[Synonym ]:
Diethyl (2-{2-[2-(2-bromoethoxy)ethoxy]ethoxy}ethyl)phosphonate
Phosphonic acid, P-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethyl]-, diethyl ester
MFCD11982880

Biological Activity

[Description]:

Bromo-PEG3-phosphonic acid diethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
426.5±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₂H₂₆BrO₆P

[ Molecular Weight ]:
377.209

[ Flash Point ]:
211.7±25.9 °C

[ Exact Mass ]:
376.065033

[ LogP ]:
-0.02

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.460

Bromo-PEG3-phosphonic acid diethyl ester

Names

Biological Activity

Chemical & Physical Properties

Related Compounds