PEG2-bis(phosphonic acid diethyl ester)

Modify Date: 2024-01-03 14:16:08

PEG2-bis(phosphonic acid diethyl ester) Structure
PEG2-bis(phosphonic acid diethyl ester) structure
Common Name PEG2-bis(phosphonic acid diethyl ester)
CAS Number 500347-73-9 Molecular Weight 378.29
Density N/A Boiling Point N/A
Molecular Formula C12H28O9P2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PEG2-bis(phosphonic acid diethyl ester)


PEG2-bis(phosphonic acid diethyl ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name PEG3-bis(phosphonic acid diethyl ester)
Synonym More Synonyms

 PEG2-bis(phosphonic acid diethyl ester) Biological Activity

Description PEG2-bis(phosphonic acid diethyl ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C12H28O9P2
Molecular Weight 378.29

 Synonyms

MFCD26127817