m-PEG-OH (MW 2000)

Modify Date: 2024-01-02 17:40:39

m-PEG-OH (MW 2000) Structure
m-PEG-OH (MW 2000) structure
Common Name m-PEG-OH (MW 2000)
CAS Number 9004-74-4 Molecular Weight 516.620
Density 1.08 Boiling Point 557.1±45.0 °C at 760 mmHg
Molecular Formula C23H48O12 Melting Point 12 ºC
MSDS Chinese USA Flash Point 268 ºC

 Use of m-PEG-OH (MW 2000)


m-PEG-OH (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name methoxypoly(ethylene glycol)
Synonym More Synonyms

 m-PEG-OH (MW 2000) Biological Activity

Description m-PEG-OH (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Density 1.08
Boiling Point 557.1±45.0 °C at 760 mmHg
Melting Point 12 ºC
Molecular Formula C23H48O12
Molecular Weight 516.620
Flash Point 268 ºC
Exact Mass 516.314575
LogP -4.38
Appearance of Characters semisolid | White to pale yellow
Vapour density >1 (vs air)
Vapour Pressure 0.0±3.4 mmHg at 25°C
Index of Refraction 1.456
Storage condition ?20°C
Water Solubility H2O: 50 mg/mL at 25 °C, clear, colorless

 Safety Information

Personal Protective Equipment Eyeshields;Gloves
Hazard Codes Xi
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS PE8271000

 Articles33

More Articles
Universal concept for the implementation of a single cleavable unit at tunable position in functional poly(ethylene glycol)s.

Biomacromolecules 14(2) , 448-59, (2013)

Poly(ethylene glycol) (PEG) with acid-sensitive moieties gained attention particularly for various biomedical applications, such as the covalent attachment of PEG (PEGylation) to protein therapeutics,...

Preliminary assessment of the safety evaluation of novel pH-sensitive hydrogel.

Eur. J. Pharm. Biopharm. 82(2) , 332-9, (2012)

In our previous work, a new kind of pH-sensitive hydrogel based on poly (lactic acid) (PLA), methoxyl poly (ethylene glycol) (MPEG) and itaconic acid (IA) was prepared by heat-initiated free radical p...

PEGylation of vesicular stomatitis virus extends virus persistence in blood circulation of passively immunized mice.

J. Virol. 87(7) , 3752-9, (2013)

We are developing oncolytic vesicular stomatitis viruses (VSVs) for systemic treatment of multiple myeloma, an incurable malignancy of antibody-secreting plasma cells that are specifically localized i...

 Synonyms

MFCD00084416
Poly(oxy-​1,​2-​ethanediyl)​, α-​methyl-​ω-​hydroxy- Polymer
2,5,8,11,14,17,20,23,26,29,32-Undecaoxatetratriacontan-34-ol
Methoxypolyethylene glycols
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