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9004-74-4

9004-74-4 structure
9004-74-4 structure

Name methoxypoly(ethylene glycol)
Synonyms MFCD00084416
Poly(oxy-​1,​2-​ethanediyl)​, α-​methyl-​ω-​hydroxy- Polymer
2,5,8,11,14,17,20,23,26,29,32-Undecaoxatetratriacontan-34-ol
Methoxypolyethylene glycols
Description m-PEG-OH (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Density 1.08
Boiling Point 557.1±45.0 °C at 760 mmHg
Melting Point 12 ºC
Molecular Formula C23H48O12
Molecular Weight 516.620
Flash Point 268 ºC
Exact Mass 516.314575
LogP -4.38
Appearance semisolid | White to pale yellow
Vapour density >1 (vs air)
Vapour Pressure 0.0±3.4 mmHg at 25°C
Index of Refraction 1.456
Storage condition ?20°C
Water Solubility H2O: 50 mg/mL at 25 °C, clear, colorless
Personal Protective Equipment Eyeshields;Gloves
Hazard Codes Xi
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS PE8271000