TCO-PNB ester

Modify Date: 2024-01-09 18:31:23

TCO-PNB ester Structure
TCO-PNB ester structure
Common Name TCO-PNB ester
CAS Number 1438415-89-4 Molecular Weight 291.30
Density N/A Boiling Point N/A
Molecular Formula C15H17NO5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TCO-PNB ester


TCO-PNB ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name TCO-PNB ester

 TCO-PNB ester Biological Activity

Description TCO-PNB ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C15H17NO5
Molecular Weight 291.30
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