1191901-33-3
1191901-33-3 structure
- Name: TCO-NHS ester
- Chemical Name: 1-({[(4Z)-4-Cycloocten-1-yloxy]carbonyl}oxy)-2,5-pyrrolidinedione
- CAS Number: 1191901-33-3
- Molecular Formula: C13H17NO5
- Molecular Weight: 267.278
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2018-06-13 03:36:48
- Modify Date: 2025-09-18 12:39:48
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TCO-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | 1-({[(4Z)-4-Cycloocten-1-yloxy]carbonyl}oxy)-2,5-pyrrolidinedione |
|---|---|
| Synonyms |
1-({[(4Z)-4-Cycloocten-1-yloxy]carbonyl}oxy)-2,5-pyrrolidinedione
2,5-Pyrrolidinedione, 1-[[[(4Z)-4-cycloocten-1-yloxy]carbonyl]oxy]- |
| Description | TCO-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl/ether |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 369.1±45.0 °C at 760 mmHg |
| Molecular Formula | C13H17NO5 |
| Molecular Weight | 267.278 |
| Flash Point | 177.0±28.7 °C |
| Exact Mass | 267.110687 |
| LogP | 1.45 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.540 |
| Hazard Codes | Xi |
|---|---|
| RIDADR | NONH for all modes of transport |