E3 Ligase Ligand-Linker Conjugate 11 is a synthesized compound which incorporates a ligand for the E3 ubiquitin ligase and a PROTAC linker to bring together target protein and ubiquitinating machinery.
Tos-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Hydroxy-PEG2-C2-sulfonic acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
E3 ligase Ligand-Linker Conjugates 12 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.
Boc-NH-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
N-Boc-cis-4-Hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-Hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the synth
N-(Tos-PEG4)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Protein degrader 1 hydrochloride is used in the synthesis of HaloPROTACs.
Pomalidomide-5-OH (5-hydroxy pomalidomide) is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTAC[1].
Thalidomide-5,6-Cl is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-Cl can be connected to the ligand for protein by a linker to form PROTACs.
A 410099.1, amine-Bocis a functionalized IAP ligand and can be used for the synthesis of PROTACs, such as PROTACs targeting BTK (PROTACs 4 and 5)[1].
Triethylene glycol monodecyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Pomalidomide-C11-NH2 hydrochloride is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.Pomalidomide-C11-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC[1].
2-(2-(6-chlorohexyloxy)ethoxy)ethanamine (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Biotin-PEG4-amino-t-Bu-DADPS-C6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
N-(m-PEG9)-N'-(PEG5-acid)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Hexane-1,6-diyldiphosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Decaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Fmoc-N-amido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
N-Ethylpropionamide-PEG1-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Cbz-NH-PEG1-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
VH032-PEG2-NH-BOC is a Boc-modified VH032 (HY-120217) that serves as a ligand for VHL and recruits von Hippel-Lindau (VHL) proteins. VH032-PEG2-NH-BOC will remove the protecting group under acidic conditions and be directly used for PROTAC molecule synthesis. VH032-PEG2-NH-BOC is a key intermediate in the synthesis of PROTAC based on VHL ligand.
PROTAC Linker 13 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 13 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Propargyl-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Pyrene-amido-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Tos-PEG6-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Bis-PEG4-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Pomalidomide-amino-PEG4-C4-Cl (Intermediate 4d) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide-amino-PEG4-C4-Cl can be used in the synthesis of PROTAC[1].
Biotin-C5-amino-C5-amino is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Protac Linker 5 is a PROTAC linker utilized to connect the respective tyrosine kinase inhibitor (TKI) to the E3 recruiting ligand.