VH 032 amide-PEG2-amine

Modify Date: 2024-01-14 09:25:40

VH 032 amide-PEG2-amine structure	Common Name	VH 032 amide-PEG2-amine
	CAS Number	2341796-76-5	Molecular Weight	648.64
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₈H₄₃Cl₂N₅O₆S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of VH 032 amide-PEG2-amine

(S,R,S)-AHPC-PEG2-NH2 dihydrochloride (VH032-PEG2-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs[1].

Name	(S,R,S)-AHPC-PEG2-NH2 dihydrochloride

Description	(S,R,S)-AHPC-PEG2-NH2 dihydrochloride (VH032-PEG2-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	VHL
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem. 2018 Jan 25;61(2):504-513.

Molecular Formula	C₂₈H₄₃Cl₂N₅O₆S
Molecular Weight	648.64

Hazard Codes	Xi

VH 032 amide-PEG2-amine

Use of VH 032 amide-PEG2-amine

Names

VH 032 amide-PEG2-amine Biological Activity

Chemical & Physical Properties

Safety Information