(S,R,S)-AHPC-C3-NH2 dihydrochloride

Modify Date: 2024-01-02 23:11:30

(S,R,S)-AHPC-C3-NH2 dihydrochloride Structure
(S,R,S)-AHPC-C3-NH2 dihydrochloride structure
Common Name (S,R,S)-AHPC-C3-NH2 dihydrochloride
CAS Number 2564467-25-8 Molecular Weight 588.59
Density N/A Boiling Point N/A
Molecular Formula C26H37N5O4S.2HCl Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (S,R,S)-AHPC-C3-NH2 dihydrochloride


(S,R,S)-AHPC-C3-NH2 (dihydrochloride) is the dihydrochloride form of (S,R,S)-AHPC-C3-NH2 (HY-130711). (S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852 (HY-130708). UNC6852 is an EED-targeted bivalent chemical degrader[1].

 Names

Name VH 032 amide-alkylC3-amine
Synonym More Synonyms

 (S,R,S)-AHPC-C3-NH2 dihydrochloride Biological Activity

Description (S,R,S)-AHPC-C3-NH2 (dihydrochloride) is the dihydrochloride form of (S,R,S)-AHPC-C3-NH2 (HY-130711). (S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852 (HY-130708). UNC6852 is an EED-targeted bivalent chemical degrader[1].
Related Catalog
References

[1]. Potjewyd F, et al. Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader. Cell Chem Biol. 2020 Jan 16;27(1):47-56.e15.  

 Chemical & Physical Properties

Molecular Formula C26H37N5O4S.2HCl
Molecular Weight 588.59

 Synonyms

(2S,4R)-1-((S)-2-(4-Aminobutanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
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