Thalidomide-4-O-CH2-COO(t-Bu)
Modify Date: 2023-01-15 20:16:10
Thalidomide-4-O-CH2-COO(t-Bu) structure
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Common Name | Thalidomide-4-O-CH2-COO(t-Bu) | ||
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| CAS Number | 1950635-36-5 | Molecular Weight | 388.37 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H20N2O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Thalidomide-4-O-CH2-COO(t-Bu)Thalidomide-4-O-CH2-COO(t-Bu) is t-Bu modified Thalidomide (HY-14658), which is the final step intermediate in the synthesis of Thalidomide-4-OH (HY-123096). Thalidomide-4-O-CH2-COO(t-Bu) acts as a Cereblon ligand to recruit CRBN proteins. The t-Bu protecting group at the end of Thalidomide-4-O-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-O-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based designed PROTAC molecules. |
| Name | tert-Butyl 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetate |
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| Synonym | More Synonyms |
| Description | Thalidomide-4-O-CH2-COO(t-Bu) is t-Bu modified Thalidomide (HY-14658), which is the final step intermediate in the synthesis of Thalidomide-4-OH (HY-123096). Thalidomide-4-O-CH2-COO(t-Bu) acts as a Cereblon ligand to recruit CRBN proteins. The t-Bu protecting group at the end of Thalidomide-4-O-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-O-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based designed PROTAC molecules. |
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| Related Catalog |
| Molecular Formula | C19H20N2O7 |
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| Molecular Weight | 388.37 |
| MFCD32643096 |