PROTAC Linker

Total: 1884
Updated: 2019-06-28 15:55:20
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.

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NF-κB >
NF-κB IKK Keap1-Nrf2 MALT1
PI3K/Akt/mTOR >
Akt AMPK ATM/ATR DNA-PK GSK-3 MELK mTOR PDK-1 PI3K PI4K PIKfyve PTEN
PROTAC >
PROTAC E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase PROTAC Linker PROTAC-linker Conjugate for PAC
Protein Tyrosine Kinase/RTK >
Ack1 ALK Bcr-Abl BMX Kinase Btk c-Fms c-Kit c-Met/HGFR Discoidin Domain Receptor DYRK EGFR Ephrin Receptor FAK FGFR FLT3 IGF-1R Insulin Receptor IRAK Itk PDGFR PKA Pyk2 ROS Src Syk TAM Receptor Trk Receptor VEGFR
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TGF-beta/Smad >
TGF-beta/Smad PKC ROCK TGF-β Receptor
Vitamin D Related >
VD/VDR
Others >
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Trityl-PEG10-azide

Trityl-PEG10-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 877239-08-2
  • MF: C39H55N3O10
  • MW: 725.868
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Benzyl-PEG5-NHBoc

Benzyl-PEG5-NHBoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2064292-55-1
  • MF: C22H37NO7
  • MW: 427.53
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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2,2-Dimethyl-4-oxo-3,8,11,14,17,20,23-heptaoxa-5-azapentacosan-25-yl 4-methylbenzenesulfonate

Boc-NH-PEG7-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1292268-14-4
  • MF: C26H45NO11S
  • MW: 579.70
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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5-endo-BCN-pentanoic acid

5-endo-BCN-pentanoic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2364591-80-8
  • MF: C16H23NO4
  • MW: 293.36
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Mal-amido-PEG9-NHBoc

Mal-amido-PEG9-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2182602-20-4
  • MF: C32H57N3O14
  • MW: 707.81
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Methoxy-Tr-NH-PEG7

Methoxy-Tr-NH-PEG7 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2353409-88-6
  • MF: C34H47NO8
  • MW: 597.74
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Mal-PEG5-PFP ester

Mal-PEG5-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1807512-46-4
  • MF: C23H26F5NO9
  • MW: 555.446
  • Catalog: PROTAC Linker
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 594.2±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 313.2±30.1 °C
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I-PEG5-OH

I-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1883516-31-1
  • MF: C10H21IO5
  • MW: 348.18
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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4-amino-N-(4-(2-cyanoethynyl)phenyl)butanamide

APN-​NH2 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1539292-61-9
  • MF: C13H13N3O
  • MW: 227.26
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Amino-PEG4-hydrazide-Boc

Amino-PEG4-hydrazide-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1263047-17-1
  • MF: C16H33N3O7
  • MW: 379.449
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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PROTAC Linker 16

PROTAC Linker 16 is a polyethylene glycol (PEG)-based PROTAC linker. PROTAC Linker 16 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

  • CAS Number: 37860-51-8
  • MF: C22H30O9S2
  • MW: 502.59800
  • Catalog: PROTAC Linker
  • Density: 1.242 g/mL at 25ºC(lit.)
  • Boiling Point: 635ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: >230 °F
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Bromo-PEG6-bromide

Bromo-PEG6-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 72713-23-6
  • MF: C14H28Br2O6
  • MW: 452.18
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Ald-Ph-PEG4-Boc

Ald-Ph-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1807518-64-4
  • MF: C23H35NO8
  • MW: 453.526
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 606.4±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 320.5±31.5 °C
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Fmoc-Gly-NH-CH2-O-CH2-Cbz

Fmoc-Gly-NH-CH2-O-CH2-Cbz is a PROTAC linker and a maleimide-GGFG peptide linker. Fmoc-Gly-NH-CH2-O-CH2-Cbz can be used in the synthesis of the Deruxtecan[1].

  • CAS Number: 1599440-07-9
  • MF: C27H26N2O6
  • MW: 474.51
  • Catalog: PROTAC Linker
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 733.0±60.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 397.1±32.9 °C
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m-PEG5-NH2

m-PEG5-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 5498-83-9
  • MF: C11H25NO5
  • MW: 251.32000
  • Catalog: PROTAC Linker
  • Density: 1.023g/cm3
  • Boiling Point: 324.5ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 143.5ºC
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Azido-PEG10-alcohol

Azido-PEG10-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 877239-09-3
  • MF: C20H41N3O10
  • MW: 483.55
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Boc-6-aminohexanoic acid

Boc-6-aminohexanoic acid is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 6404-29-1
  • MF: C11H21NO4
  • MW: 231.289
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 380.3±25.0 °C at 760 mmHg
  • Melting Point: 35-40 °C
  • Flash Point: 183.8±23.2 °C
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N-(Azido-PEG2)-N-bis(PEG4-t-butyl ester)

N-(Azido-PEG2)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2112731-81-2
  • MF: C36H70N4O14
  • MW: 782.96
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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THP-PEG5-OH

THP-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 146395-14-4
  • MF: C15H30O7
  • MW: 322.395
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 432.5±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 215.4±28.7 °C
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PEG3-bis(phosphonic acid diethyl ester)

PEG3-bis(phosphonic acid diethyl ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1807539-03-2
  • MF: C14H32O10P2
  • MW: 422.35
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG2-C1-Boc

Azido-PEG2-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 251564-45-1
  • MF: C10H19N3O4
  • MW: 245.27600
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Mal-peg2-t-butyl ester

Mal-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1374666-31-5
  • MF: C15H23NO6
  • MW: 313.35
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Boc-N-Amido-PEG2-C2-azide

Boc-N-Amido-PEG2-C2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 950683-55-3
  • MF: C11H22N4O4
  • MW: 274.31700
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Hydroxy-PEG3-ethyl acetate

Hydroxy-PEG3-ethyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 118988-04-8
  • MF: C10H20O6
  • MW: 236.26200
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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