4-amino-N-(4-(2-cyanoethynyl)phenyl)butanamide

Modify Date: 2025-08-24 21:33:05

4-amino-N-(4-(2-cyanoethynyl)phenyl)butanamide Structure
4-amino-N-(4-(2-cyanoethynyl)phenyl)butanamide structure
Common Name 4-amino-N-(4-(2-cyanoethynyl)phenyl)butanamide
CAS Number 1539292-61-9 Molecular Weight 227.26
Density N/A Boiling Point N/A
Molecular Formula C13H13N3O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 4-amino-N-(4-(2-cyanoethynyl)phenyl)butanamide


APN-​NH2 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name APN-​NH2

  Biological Activity

Description APN-​NH2 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl-Chain

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C13H13N3O
Molecular Weight 227.26
InChIKey RLTVJTXRTMTNBC-UHFFFAOYSA-N
SMILES N#CC#Cc1ccc(NC(=O)CCCN)cc1
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